A novel hexaketide naphthalene synthesized by a chimeric polyketide synthase composed of fungal pentaketide and heptaketide synthases

被引：28

作者：

Watanabe, A ^{[1
]}

Ebizuka, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 05期

基金：

日本学术振兴会;

关键词：

polyketides; naphthalene; fungi; chimera; biosynthesis;

D O I：

10.1016/S0040-4039(01)02251-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aspergillus nidulans wA and Colletotrichum lagenarium pks1 code for iterative type I polyketide synthases (PKSs) and synthesize heptaketide naphthopyrone and pentaketide naphthalene, respectively. A chimeric PKS, called SW-B, composed of WA and PKS1 synthesized mainly hexaketide isocoumarin and all unknown yellow compound. The latter was identified as the novel hexaketide 2-acetyl-1,3,6,8-tetrahydroxynaphthalene. These findings indicate broad substrate specificity of the WA C-terminal domain for Claisen-type cyclization and an unprecedented chain length determination mechanism of fungal aromatic PKSs. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：843 / 846

页数：4

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