Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth

被引：799

作者：

Katakowski, Mark ^{[1
]}

Buller, Ben ^{[1
]}

Zheng, Xuguang ^{[1
]}

Lu, Yong ^{[1
]}

Rogers, Thomas ^{[1
]}

Osobamiro, Oyinkansola ^{[1
]}

Shu, Wayne ^{[1
]}

Jiang, Feng ^{[1
]}

Chopp, Michael ^{[1
,2
]}

机构：

[1] Henry Ford Hosp, Dept Neurol, Detroit, MI 48202 USA

[2] Oakland Univ, Dept Phys, Rochester, MI USA

来源：

CANCER LETTERS | 2013年 / 335卷 / 01期

关键词：

Glioma; MicroRNA; Mesenchymal stem cell; miR-146b; Exosome; SIGNAL-TRANSDUCTION; FACTOR RECEPTOR; MICRORNA; RESECTION; SMAD4;

D O I：

10.1016/j.canlet.2013.02.019

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Exosomes are 30-150 nm vesicles secreted by a wide range of mammalian cells that can contain microRNA (miRNA). To test if marrow stromal cell (MSC) exosomes could be used as a vehicle for delivery of anti-tumor miRNAs, we transfected MSCs with a miR-146b expression plasmid, and harvested exosomes released by the MSCs. Intra-tumor injection of exosomes derived from miR-146-expressing MSCs significantly reduced glioma xenograft growth in a rat model of primary brain tumor. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：201 / 204

页数：4

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