Epigenetic changes in gliomas

被引：38

作者：

Burgess, Rebecca ^{[1
]}

Jenkins, Robert ^{[1
]}

Zhang, Zhiguo ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

来源：

CANCER BIOLOGY & THERAPY | 2008年 / 7卷 / 09期

关键词：

PTEN; PI3K; cell cycle; p53; nuclear PTEN and glioblastoma;

D O I：

10.4161/cbt.7.9.6992

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Epigenetics are defined, in broad-terms, as alterations in gene expression without changes in DNA sequence. While histone modifications and DNA methylation are two classical means to regulate gene expression, miRNA has also recently been documented to govern gene expression in normal as well as cancer cells. In this review, we will first describe briefly histone modifications, DNA methylation and miRNAs and the functions of these epigenetic marks during different cellular processes involving DNA metabolism. We will then highlight some epigenetic changes in glioblastomas, a malignant form of brain tumor, and potential application of epigenetic means for diagnosis, prognosis, and treatment of gliomas. We expect that novel therapies will be developed to counter epigenetic changes in this deadly disease.

引用

页码：1326 / 1334

页数：9

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