Can growth hormone treatment in boys without growth hormone deficiency impair testicular function?

被引：19

作者：

Bertelloni, S

Baroncelli, GI

Viacava, P

Massimetti, M

Simi, P

Saggese, G

机构：

[1] Univ Pisa, Santa Chiara Hosp, Dept Reprod Med & Pediat, Pediat Div 2,Adolescent Unit, I-56125 Pisa, Italy

[2] Univ Pisa, Santa Chiara Hosp, Dept Reprod Med & Pediat, Pediat Div 2,Pediat Endocrine Unit, I-56125 Pisa, Italy

[3] Univ Pisa, Santa Chiara Hosp, Dept Oncol, Pathol Lab, I-56125 Pisa, Italy

[4] Univ Pisa, Santa Chiara Hosp, Cytogenet & Mol Biol Lab, I-56125 Pisa, Italy

来源：

JOURNAL OF PEDIATRICS | 1999年 / 135卷 / 03期

关键词：

D O I：

10.1016/S0022-3476(99)70136-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 [儿科学];

摘要：

Four young male subjects (age range, 17 4/12 to 25 5/12 years), previously treated with human growth hormone for non-growth hormone-dependent short stature, showed reduced testicular volume and hypergonadotropic hypogonadism. They also showed impaired spermatogenesis and altered testicular texture as determined by ultrasonography. No clinical or laboratory finding showed disease associated with testicular dysfunction. An unfavorable gonadal outcome could occur in boys without growth hormone deficiency treated with human growth hormone.

引用

页码：367 / 370

页数：4

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