Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques

被引：359

作者：

Deng, Wei ^{[1
,2
]}

Bao, Linlin ^{[1
,2
]}

Liu, Jiangning ^{[1
,2
]}

Xiao, Chong ^{[1
,2
]}

Liu, Jiayi ^{[3
]}

Xue, Jing ^{[1
,2
]}

Lv, Qi ^{[1
,2
]}

Qi, Feifei ^{[1
,2
]}

Gao, Hong ^{[1
,2
]}

Yu, Pin ^{[1
,2
]}

Xu, Yanfeng ^{[1
,2
]}

Qu, Yajin ^{[1
,2
]}

Li, Fengdi ^{[1
,2
]}

Xiang, Zhiguang ^{[1
,2
]}

Yu, Haisheng ^{[1
,2
]}

Gong, Shuran ^{[1
,2
]}

Liu, Mingya ^{[1
,2
]}

Wang, Guanpeng ^{[1
,2
]}

Wang, Shunyi ^{[1
,2
]}

Song, Zhiqi ^{[1
,2
]}

Liu, Ying ^{[1
,2
]}

Zhao, Wenjie ^{[1
,2
]}

Han, Yunlin ^{[1
,2
]}

Zhao, Linna ^{[1
,2
]}

Liu, Xing ^{[1
,2
]}

Wei, Qiang ^{[1
,2
]}

Qin, Chuan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Lab Anim Sci, NHC Key Lab Human Dis Comparat Med, Beijing Key Lab Anim Models Emerging & Remerging, Beijing, Peoples R China

[2] Peking Union Med Coll, Comparat Med Ctr, Beijing, Peoples R China

[3] Capital Med Univ, Beijing Anzhen Hosp, Dept Radiol, Beijing, Peoples R China

来源：

SCIENCE | 2020年 / 369卷 / 6505期

关键词：

SARS;

D O I：

10.1126/science.abc5343

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral dissemination, clinical manifestations of viral disease, or histopathological changes. Comparing the humoral and cellular immunity between primary infection and rechallenge revealed notably enhanced neutralizing antibody and immune responses. Our results suggest that primary SARS-CoV-2 exposure protects against subsequent reinfection in rhesus macaques.

引用

页码：818 / +

页数：16

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