Transabdominal oxygenation using perfluorocarbons

被引:8
作者
Chiba, T
Harrison, MR
Ohkubo, T
Rollins, MD
Talbanese, CT
Jennings, RW
机构
[1] Univ Calif San Francisco, Fetal Treatment Ctr, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Dept Surg, Wound Healing Res Lab, San Francisco, CA 94143 USA
关键词
perfluorocarbons; perfluorotripropylamine; transabdominal oxygenation (intraperitoneal; intraluminal);
D O I
10.1016/S0022-3468(99)90394-9
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Purpose: Evaluation of the intraabdominal (intraperitoneal and intraluminal) administration of oxygen-saturated perfluorocarbon on both portal and arterial blood oxygenation. Methods: Eight male rabbits were divided into the test (n = 5) and control (n = 3) groups. Each underwent intrajejunal, intraperitoneal, and intravascular (artery, portal vein) catheter placements along with ligation of the duodenum and the terminal ileum under general anesthesia. The test group received oxygen-saturated perfluorotripropylamine (FTPA), and the control group received oxygen desaturated FTPA. The oxygen delivery was assessed by serial blood gas measurements before and after the administration of FTPA. Results: The administration of oxygen-saturated FTPA significantly increased the partial pressure of oxygen within both the arterial and the portal venous blood (PaO2, PpVO(2)) without significant changes in PCO2 Values. Oxygen desaturated FTPA failed to show any effects on blood gas values. Compared with oxygen desaturated FTPA, oxygen-saturated FTPA increased PaO2, PpVO(2), and oxygen saturation (artery, portal vein) significantly at some, but not all of the time-points measured. Conclusions: The intraabdominal administration of saturated FTPA improved both the portal venous and the arterial oxygenation. This new mode of oxygenation may be helpful as an adjunct to conventional oxygen delivery systems. Copyright (C) 1999 by W.B. Saunders Company.
引用
收藏
页码:895 / 900
页数:6
相关论文
共 17 条
[11]   Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury [J].
ODonnell, KA ;
Caty, MG ;
Zheng, S ;
Rossman, JE ;
Azizkhan, RG .
JOURNAL OF PEDIATRIC SURGERY, 1997, 32 (02) :361-365
[12]   TREATMENT OF INTESTINAL ISCHEMIA WITH OXYGENATED INTRALUMINAL PERFLUOROCARBONS [J].
OLDHAM, KT ;
GUICE, KS ;
GORE, D ;
GOURLEY, WK ;
LOBE, TE .
AMERICAN JOURNAL OF SURGERY, 1987, 153 (03) :291-294
[13]   INTERSTITIAL FLUID ACCUMULATION DOES NOT INFLUENCE OXYGEN-UPTAKE IN THE RABBIT SMALL-INTESTINE [J].
OSTGAARD, G ;
REED, RK .
ACTA ANAESTHESIOLOGICA SCANDINAVICA, 1995, 39 (02) :167-173
[14]   Partial liquid ventilation in newborn patients with congenital diaphragmatic hernia [J].
Pranikoff, T ;
Gauger, PG ;
Hirschl, RB .
JOURNAL OF PEDIATRIC SURGERY, 1996, 31 (05) :613-618
[15]   Mucosal protection from intestinal ischemia-reperfusion reduces oxidant injury to the lung [J].
Rossman, JE ;
Caty, MG ;
Zheng, S ;
Karamanoukian, HL ;
Thusu, K ;
Azizkhan, RG ;
Dandona, P .
JOURNAL OF SURGICAL RESEARCH, 1997, 73 (01) :41-46
[16]  
Stolar C.J.H., 1998, PAEDIAT SURG, P819
[17]  
SUZUKI K, 1977, VARIOUS PHYSL VALUES, P87