2-chloro-1,3-dimethylimidazolinium chloride. 1. A powerful dehydrating equivalent to DCC

被引：137

作者：

Isobe, T

Iskikawa, T

机构：

[1] Chiba Univ, Fac Pharmaceut Sci, Inage Ku, Chiba 2638522, Japan

[2] Shiratori Pharmaceut Co Ltd, Cent Res Lab, Chiba 2750016, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 19期

关键词：

D O I：

10.1021/jo990210y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (3) can act as a powerful dehydrating agent, replacing DCC (1) under nearly neutral conditions. Its application to acylation and dehydration is described.

引用

页码：6984 / 6988

页数：5

共 46 条

[1]

Anderson R.J., 1989, DE, Patent No. [3902818., 3902818]

[2] N,N'-cyclization of carbodiimides with 2-(bromomethyl)acrylic acid. A direct entry to the system 5-methylene-6H-pyrimidine-2,4-dione, a new class of thymine analogues [J].

Anglada, JM ;

Campos, T ;

Camps, F ;

Moreto, JM ;

Pages, L .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (04) :1259-1270

[3] A new class of highly potent farnesyl diphosphate-competitive inhibitors of farnesyltransferase [J].

Aoyama, T ;

Satoh, T ;

Yonemoto, M ;

Shibata, J ;

Nonoshita, K ;

Arai, S ;

Kawakami, K ;

Iwasawa, Y ;

Sano, H ;

Tanaka, K ;

Monden, Y ;

Kodera, T ;

Arakawa, H ;

Suzuki-Takahashi, I ;

Kamei, T ;

Tomimoto, K .

JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (02) :143-147

[4] A NEW COUPLING REAGENT FOR PEPTIDE-SYNTHESIS - BENZOTRIAZOLYLOXY-BIS(PYRROLIDINO)-CARBONIUM HEXAFLUOROPHOSPHATE (BBC) [J].

CHEN, SQ ;

XU, JC .

TETRAHEDRON LETTERS, 1992, 33 (05) :647-650

[5] A MILD AND EFFICIENT PREPARATION OF CARBODIIMIDES [J].

FELL, JB ;

COPPOLA, GM .

SYNTHETIC COMMUNICATIONS, 1995, 25 (01) :43-47

[6]

FIESER LF, 1967, REAGENTS OGANIC SYNT, V1, P274

[7]

FIESER LF, 1967, REAGENTS ORGANIC SYN, V1, P231

[8] N,N,N',N'-TETRAMETHYLCHLOROFORMAMIDINIUM CHLORIDE AS AN EFFICIENT CONDENSATION REAGENT FOR A NOVEL ESTERIFICATION APPLICABLE TO THE MACROLIDE SYNTHESIS [J].

FUJISAWA, T ;

MORI, T ;

FUKUMOTO, K ;

SATO, T .

CHEMISTRY LETTERS, 1982, (12) :1891-1894

[9] ONE-POT SYNTHESIS OF ACID ANHYDRIDES FROM ACIDS USING N,N,N',N'-TETRAMETHYLCHLOROFORMAMIDINIUM CHLORIDE UNDER MILD CONDITIONS [J].

FUJISAWA, T ;

TAJIMA, K ;

SATO, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1983, 56 (11) :3529-3530

[10] REACTIONS IN CARBOXYLIC ACID THIONYL CHLORIDE SYSTEMS [J].

GERRARD, W ;

THRUSH, AM .

JOURNAL OF THE CHEMICAL SOCIETY, 1953, (JUL) :2117-2120

← 1 2 3 4 5 →