HIV-1 and HAART: A time to cure, a time to kill

被引：42

作者：

Saag, MS ^{[1
]}

Kilby, JM ^{[1
]}

机构：

[1] Univ Alabama, Dept Med, AIDS Clin Trials Unit, Birmingham, AL 35294 USA

来源：

NATURE MEDICINE | 1999年 / 5卷 / 06期

关键词：

D O I：

10.1038/9452

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two clinical studies show a failure of conventional anti-retroviral therapy in achieving complete HIV eradication; 10–60 years are deemed necessary to eliminate HIV.

引用

页码：609 / 611

页数：3

共 10 条

[1] Immune clearance of HIV type 1 replication-active cells: A model of two patterns of steady state HIV infection [J].

Bucy, RP .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (03) :223-227

[2] Early establishment of a pool of latently infected, resting CD4+ T cells during primary HIV-1 infection [J].

Chun, TW ;

Engel, D ;

Berrey, MM ;

Shea, T ;

Corey, L ;

Fauci, AS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (15) :8869-8873

[3] Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy [J].

Finzi, D ;

Blankson, J ;

Siliciano, JD ;

Margolick, JB ;

Chadwick, K ;

Pierson, T ;

Smith, K ;

Lisziewicz, J ;

Lori, F ;

Flexner, C ;

Quinn, TC ;

Chaisson, RE ;

Rosenberg, E ;

Walker, B ;

Gange, S ;

Gallant, J ;

Siliciano, RF .

NATURE MEDICINE, 1999, 5 (05) :512-517

[4] Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [J].

Finzi, D ;

Hermankova, M ;

Pierson, T ;

Carruth, LM ;

Buck, C ;

Chaisson, RE ;

Quinn, TC ;

Chadwick, K ;

Margolick, J ;

Brookmeyer, R ;

Gallant, J ;

Markowitz, M ;

Ho, DD ;

Richman, DD ;

Siliciano, RF .

SCIENCE, 1997, 278 (5341) :1295-1300

[5]

HOCKETT R, IN PRESS J EXP MED

[6] Dramatic rise in plasma viremia after CD8+ T cell depletion in simian immunodeficiency virus-infected macaques [J].

Jin, X ;

Bauer, DE ;

Tuttleton, SE ;

Lewin, S ;

Gettie, A ;

Blanchard, J ;

Irwin, CE ;

Safrit, JT ;

Mittler, J ;

Weinberger, L ;

Kostrikis, LG ;

Zhang, LQ ;

Perelson, AS ;

Ho, DD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (06) :991-998

[7] Decay characteristics of HIV-1-infected compartments during combination therapy [J].

Perelson, AS ;

Essunger, P ;

Cao, YZ ;

Vesanen, M ;

Hurley, A ;

Saksela, K ;

Markowitz, M ;

Ho, DD .

NATURE, 1997, 387 (6629) :188-191

[8] Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes [J].

Schmitz, JE ;

Kuroda, MJ ;

Santra, S ;

Sasseville, VG ;

Simon, MA ;

Lifton, MA ;

Racz, P ;

Tenner-Racz, K ;

Dalesandro, M ;

Scallon, BJ ;

Ghrayeb, J ;

Forman, MA ;

Montefiori, DC ;

Rieber, EP ;

Letvin, NL ;

Reimann, KA .

SCIENCE, 1999, 283 (5403) :857-860

[9] Recovery of replication-competent HIV despite prolonged suppression of plasma viremia [J].

Wong, JK ;

Hezareh, M ;

Gunthard, HF ;

Havlir, DV ;

Ignacio, CC ;

Spina, CA ;

Richman, DD .

SCIENCE, 1997, 278 (5341) :1291-1295

[10]

ZHANG L, IN PRESS N ENGL J ME

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