Anticancer drug design based on plant-derived natural products

被引：65

作者：

Lee, KH ^{[1
]}

机构：

[1] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

JOURNAL OF BIOMEDICAL SCIENCE | 1999年 / 6卷 / 04期

关键词：

anticancer agents; drug design; natural products; synthetic analogs;

D O I：

10.1007/BF02253565

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review article focuses on recent research in my laboratory on various classes of compounds that possess potent antitumor activity, These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analog synthesis, Structural modification, structure-activity relationship, and mechanism of action studies will be discussed.

引用

页码：236 / 250

页数：15

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