The advent of highly selective inhibitors of cyclooxygenase - A review

被引：71

作者：

Cryer, B

Dubois, A

机构：

[1] Vet Adm Med Ctr, Med Serv, Dallas, TX 75216 USA

[2] Univ Texas, SW Med Ctr, Dept Internal Med, Dallas, TX USA

[3] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Med, Bethesda, MD 20814 USA

[4] Uniformed Serv Univ Hlth Sci, F Edward Hebert Sch Med, Dept Surg, Bethesda, MD 20814 USA

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1998年 / 56卷 / 5-6期

关键词：

cyclooxygenase; 1; 2; gastro-intestinal tract;

D O I：

10.1016/S0090-6980(98)00064-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclooxygenase (COX) exists in two isoforms, COX-1 and COX-2. COX-1 is present and is constitutively expressed in most cells and tissues, whereas COX-2 is felt to principally mediate inflammation. However, this distinction appears to be challenged by recent observations. This review addresses the roles of COX-1 and COX-2 isoforms in physiologic and pathophysiologic states and reviews potential therapeutic roles for selective COX inhibitors.

引用

页码：341 / 361

页数：21

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