Ethanol extract of Rehmannia glutinosa exerts antidepressant-like effects on a rat chronic unpredictable mild stress model by involving monoamines and BDNF

被引:65
作者
Wang, Jun-Ming [1 ,2 ]
Pei, Li-Xin [1 ]
Zhang, Yue-Yue [1 ]
Cheng, Yong-Xian [3 ]
Niu, Chun-Ling [4 ]
Cui, Ying [1 ,2 ]
Feng, Wei-Sheng [1 ,2 ]
Wang, Gui-Fang [1 ]
机构
[1] Henan Univ Chinese Med, Coll Pharm, East Jinshui Rd & Boxue Rd, Zhengzhou 450046, Henan, Peoples R China
[2] Henan Univ Tradit Chinese Med, Collaborat Innovat Ctr Resp Dis Diag & Treatment, Zhengzhou 450046, Henan, Peoples R China
[3] Shenzhen Univ, Hlth Sci Ctr, Shenzhen 518060, Peoples R China
[4] Henan Univ Chinese Med, Coll Basic Med, Zhengzhou 450046, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
Antidepressant; Rehmannia glutinosa; BDNF; Monoamineergic nervous system; Chronic unpredictable mild stress; HIPPOCAMPAL NEUROGENESIS; HPA AXIS; DEPRESSION; INVOLVEMENT; MICE; SYSTEM; NOREPINEPHRINE; CORTICOSTERONE; IMPAIRMENT; BEHAVIOR;
D O I
10.1007/s11011-018-0202-x
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
The dried roots of Rehmannia glutinosa Libosch. (Scrophulariaceae) are of both medicinal and nutritional importance. Our previous study has found that the 80% ethanol extract of R. glutinosa (RGEE) produced antidepressant-like activities in mouse behavioral despair depression models. However, its mechanisms are still unclear. The present study aimed to observe the antidepressant-like mechanisms of RGEE on a rat chronic unpredictable mild stress (CUMS) model by involving monoaminergic neurotransmitters and brain-derived neurotrophic factor (BDNF). CUMS-stressed rats were orally given RGEE daily (150, 300, and 600 mg/kg) or fluoxetine hydrochloride (FH) for 3 weeks after starting the CUMS procedure. Sucrose preference test was carried out to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analysis. Results demonstrated that CUMS induced depression-like behavior, whereas RGEE and FH administration inhibited this symptom. Furthermore, CUMS caused excessively elevated levels of serum corticosterone (CORT), an index of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, in a manner attenuated by RGEE and FH administration. RGEE administration also further elevated monoamine neurotransmitters and BDNF levels, up-regulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB) in hippocampus of rats suffering CUMS. Together, our findings suggest that RGEE can improve CUMS-evoked depression-like behavior, and indicate its mechanisms may partially be associated with restoring HPA axis dysfunctions, enhancing monoamineergic nervous systems, and up-regulating BDNF and TrkB expression.
引用
收藏
页码:885 / 892
页数:8
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