Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

被引：114

作者：

Liu, JS ^{[1
]}

Lynch, PA ^{[1
]}

Chien, CY ^{[1
]}

Montelione, GT ^{[1
]}

Krug, RM ^{[1
]}

Berman, HM ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,WRIGHT RIEMAN LABS,DEPT CHEM,PISCATAWAY,NJ 08854

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 11期

关键词：

D O I：

10.1038/nsb1197-896

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nonstructural protein (NS1 protein) of the influenza A virus hinds to several types of RNAs. X-ray crystallographic analysis of the RNA-binding domain reveals a unique topology for the monomer as well as a novel six-helix structure for the dimer.

引用

页码：896 / 899

页数：4

共 30 条

[1] Methods used in the structure determination of bovine mitochondrial F-1 ATPase
Abrahams, JP
Leslie, AGW
[J]. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1996, 52 : 30 - 42
[2] [Anonymous], ACTA CRYSTALLOGR D
[3] STRUCTURE OF THE CO1E1 ROP PROTEIN AT 1.7 A RESOLUTION
BANNER, DW
KOKKINIDIS, M
TSERNOGLOU, D
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1987, 196 (03) : 657 - 675
[4] alpha helix-RNA major groove recognition in an HIV-1 Rev peptide RRE RNA complex
Battiste, JL
Mao, HY
Rao, NS
Tan, RY
Muhandiram, DR
Kay, LE
Frankel, AD
Williamson, JR
[J]. SCIENCE, 1996, 273 (5281) : 1547 - 1551
[5] THE WINGED-HELIX DNA-BINDING MOTIF - ANOTHER HELIX-TURN-HELIX TAKEOFF
BRENNAN, RG
[J]. CELL, 1993, 74 (05) : 773 - 776
[6] CRYSTALLOGRAPHIC R-FACTOR REFINEMENT BY MOLECULAR-DYNAMICS
BRUNGER, AT
KURIYAN, J
KARPLUS, M
[J]. SCIENCE, 1987, 235 (4787) : 458 - 460
[7] A novel RNA-binding motif in influenza A virus non-structural protein 1
Chien, CY
Tejero, R
Huang, YP
Zimmerman, DE
Rios, CB
Krug, RM
Montelione, GT
[J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (11) : 891 - 895
[8] STRUCTURAL SUPERPOSITION OF PROTEINS WITH UNKNOWN ALIGNMENT AND DETECTION OF TOPOLOGICAL SIMILARITY USING A 6-DIMENSIONAL SEARCH ALGORITHM
DIEDERICHS, K
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1995, 23 (02): : 187 - 195
[9] RNA recognition and translational regulation by a homeodomain protein
Dubnau, J
Struhl, G
[J]. NATURE, 1996, 379 (6567) : 694 - 699
[10] FUREY W, 1997, IN PRESS METH ENZ

← 1 2 3 →