Effects of luteolin 5-O-beta-rutinoside in streptozotocin-induced diabetic rats

被引：31

作者：

Zarzuelo, A

Jimenez, I

Gamez, MJ

Utrilla, P

Fernadez, I

Torres, MI

Osuna, I

机构：

[1] UNIV GRANADA,FAC MED,DEPT BIOQUIM,E-18071 GRANADA,SPAIN

[2] UNIV GRANADA,FAC CIENCIAS,DEPT BIOL CELULAR,E-18071 GRANADA,SPAIN

来源：

LIFE SCIENCES | 1996年 / 58卷 / 25期

关键词：

luteolin; 5-O-beta-rutinoside; streptozotocin-induced diabetic rats; pancreatic regeneration;

D O I：

10.1016/0024-3205(96)00231-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have investigated the antidiabetic activity of luteolin 5-rutinoside in streptozotocin(STZ)-induced diabetic rats. Treatment for 20 days with 2 mg/kg increased both pancreatic insulin and DNA content. When both luteolin 5-rutinoside (2 mg/kg) and glibenclamide (1 mg/kg) were administered concurrently to STZ-diabetic rats, a marked antidiabetic activity was achieved. This effect was evidenced by a significant decrease in glycemia levels (> 50%), a 2.5-fold increase in insulin blood levels and an increase in body and pancreas weight, compared to the diabetic control group.

引用

页码：2311 / 2316

页数：6

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