Combined modality immunotherapy and chemotherapy: a new perspective

被引：53

作者：

Ramakrishnan, Rupal ^{[1
]}

Antonia, Scott ^{[1
]}

Gabrilovich, Dmitry I. ^{[1
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL 33612 USA

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2008年 / 57卷 / 10期

关键词：

D O I：

10.1007/s00262-008-0531-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The results of recent clinical trials have demonstrated that cancer vaccines continue to struggle to achieve tangible clinical benefits as monotherapy. Tumor-induced abnormalities in the immune system hamper anti-tumor T cell responses limiting the effectiveness of cancer immunotherapy. Recently, evidence has been mounting to suggest that immunotherapy has the possibility of achieving better success when used in combination with conventional chemotherapy. In clinical trials, immune responses elicited by cancer vaccines appear to augment the effectiveness of subsequent conventional cancer therapies.

引用

页码：1523 / 1529

页数：7

共 61 条

[31] Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy [J].

Muller, AJ ;

DuHadaway, JB ;

Donover, PS ;

Sutanto-Ward, E ;

Prendergast, GC .

NATURE MEDICINE, 2005, 11 (03) :312-319

[32] Indoleamine 2,3-dioxygenase and tumor-induced tolerance [J].

Munn, David H. ;

Mellor, Andrew L. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (05) :1147-1154

[33] Dendritic cell-based full-length survivin vaccine in treatment of experimental tumors [J].

Nagaraj, Srinivas ;

Pisarev, Vladimir ;

Kinarsky, Leo ;

Sherman, Simon ;

Muro-Cacho, Carlo ;

Altieri, Dario C. ;

Gabrilovich, Dmitry I. .

JOURNAL OF IMMUNOTHERAPY, 2007, 30 (02) :169-179

[34] Peptide vaccine given with a Toll-like receptor agonist is effective for the treatment and prevention of spontaneous breast tumors [J].

Nava-Parada, Pilar ;

Forni, Guido ;

Knutson, Keith L. ;

Pease, Larry R. ;

Celis, Esteban .

CANCER RESEARCH, 2007, 67 (03) :1326-1334

[35] Mechanism of all-trans retinoic acid effect on tumor-associated myeloid-derived suppressor cells [J].

Nefedova, Yulia ;

Fishman, Mayer ;

Sherman, Simon ;

Wang, Xingyn ;

Beg, Amer A. ;

Gabrilovich, Dmitry I. .

CANCER RESEARCH, 2007, 67 (22) :11021-11028

[36]

Nikitina EY, 2001, CLIN CANCER RES, V7, P127

[37] An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53 [J].

Nikitina, EY ;

Chada, S ;

Muro-Cacho, C ;

Fang, B ;

Zhang, R ;

Roth, JA ;

Gabrilovich, DI .

GENE THERAPY, 2002, 9 (05) :345-352

[38]

Nikitina EY, 2001, INT J CANCER, V94, P825, DOI 10.1002/1097-0215(20011215)94:6<825::AID-IJC1545>3.0.CO

[39]

2-5

[40]

Nimmanapalli R, 2001, CANCER RES, V61, P759

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