Preparation of a hyaluronic acid hydrogel through polyion complex formation using cationic polylactide-based microspheres as a biodegradable cross-linking agent

被引：29

作者：

Arimura, H

Ouchi, T ^{[1
]}

Kishida, A

Ohya, Y

机构：

[1] Kansai Univ, Dept Appl Chem, Fac Engn & High Technol Res Ctr, Osaka 5648680, Japan

[2] Natl Cardiovasc Ctr, Res Inst, Dept Biomed Engn, Osaka 5658565, Japan

来源：

JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | 2005年 / 16卷 / 11期

基金：

日本学术振兴会;

关键词：

hyaluronic acid; polyion complex; microsphere; hydrogel; charge ratio;

D O I：

10.1163/156856205774472353

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A novel hyaluronic acid (HA)-based hydrogel was prepared through polyion complex (PIC) formation between cationic polylactide (PLA)-based microspheres (MS+) and hyaluronic acid (HA(-)) as an anionic polyelectrolyte. The MS+ and HA formed a biodegradable PIC hydrogel (HA(-)/MS+) when mixed in aqueous media. The swelling behavior and mechanical properties of the PIC hydrogel could be controlled by changing the charge ratio between HA(-) and MS+. In addition, the HA(-)/MS+ PIC hydrogel resulted in a lower inflammatory response compared with a collagen hydrogel in vivo.

引用

页码：1347 / 1358

页数：12

共 34 条

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