Plasma and urine levels of adrenomedullin and proadrenomedullin N-terminal 20 peptide in chronic glomerulonephritis

被引:17
作者
Kinoshita, H [1 ]
Fujimoto, S [1 ]
Kitamura, K [1 ]
Yokota, N [1 ]
Kawamoto, M [1 ]
Tokura, T [1 ]
Hisanaga, S [1 ]
Eto, T [1 ]
机构
[1] Miyazaki Med Coll, Dept Internal Med 1, Miyazaki 8891692, Japan
关键词
adrenomedullin; proadrenomedullin N-terminal 20 peptide; chronic glomerulonephritis; nephrotic syndrome; natriuresis;
D O I
10.1016/S0272-6386(99)70116-2
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Proadrenomedullin N-terminal 20 peptide (PAMP) is a novel hypotensive peptide present in the precursor of adrenomedullin (AM), a vasodilative and natriuretic peptide. We examined the plasma and urinary levels of these peptides in patients with chronic glomerulonephritis (CGN). The mean plasma AM concentration of the patients with CGN did not differ from that of control subjects (4.17 +/- 0.17 v 3.87 +/- 0.21 fmof/ml, respectively), whereas urinary AM excretion was significantly less in the patients with CGM (5.96 +/- 0.95 v control, 8.93 +/- 1.02 fmol/mg of creatinine; P < 0.05). Plasma concentrations and urinary excretion of PAMP were significantly less for the patients with CGN compared with control subjects (0.91 +/- 0.08 v 1.23 +/- 0.20 fmol/mL; P < 0.05 and 25.0 +/- 3.0 v 35.0 +/- 3.6 fmol/mg of creatinine, respectively; P < 0.05). The plasma AM concentration was negatively correlated with plasma renin activity (r = -0.58; P < 0.01) and aldosterone concentration (r = -0.40; P < 0.05), Urinary excretions of AM and PAMP showed significant correlations with urine excretion of sodium (r = 0.39; P < 0.05 and r = 0.49; P < 0.01, respectively). These findings suggest that AM and PAMP may have roles in the regulation of sodium in patients with CGN. (C) 1999 by the National Kidney Foundation, Inc.
引用
收藏
页码:114 / 119
页数:6
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