Effects of Local Anesthetic Concentration and Dose on Continuous Interscalene Nerve Blocks: A Dual-Center, Randomized, Observer-Masked, Controlled Study

Background and Objectives: It is currently unknown if the primary determinant Of Continuous peripheral nerve block effects is simply total drug dose, or whether local anesthetic concentration and/or volume have all influence. We therefore tested the null hypothesis that providing ropivacaine at different concentrations and rates - but at an equal total basal dose - produces similar effects when used in a Continuous interscalene nerve block. Methods: Preoperatively, all anterolateral interscalene perineural catheter was inserted using the anterolateral approach in patients undergoing moderately painful shoulder surgery. Subjects were randomly assigned to receive a postoperative perineural infusion of either 0.2% ropivacaine (basal 8 mL/h, bolus 4 mL) or 0.4% ropivacaine (basal 4 mL/h, bolus 2 mL) through the second postoperative day. Our primary endpoint was the incidence of all insensate hand/finger during the 24 hours beginning the morning following Surgery. Results: The incidence of all insensate hand/finger did not differ between the treatment groups (n = 50) to a statistically significant degree (0.2% ropivacaine, mean [SD] of 0.8 [1.3] times; 0.4% ropivacaine, mean 0.3 [0.6] times; estimated difference = 0.5 episodes, 95% confidence interval, -0.1 to 1.1 episodes; P = .080). However, this is statistically inconclusive given the confidence interval. in contrast, pain (P = .020) and dissatisfaction (P = .011) were greater in patients given 0.4% ropivacaine. Conclusions: For Continuous interscalene nerve blocks, given the statistically inconclusive primary endpoint results and design limitations of the Current Study, further research on this topic is warranted. In contrast, providing a lower concentration of local anesthetic at a higher basal rate provided Superior analgesia. Reg Anesth Pain Med 2008; 33:518-525.