A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

被引：550

作者：

Sabio, Guadalupe ^{[1
,2
]}

Das, Madhumita ^{[2
]}

Mora, Alfonso ^{[2
]}

Zhang, Zhiyou

Jun, John Y. ^{[3
]}

Ko, Hwi Jin

Barrett, Tamera ^{[2
]}

Kim, Jason K.

Davis, Roger J. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Sch Med, Howard Hughes Med Inst, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[3] Penn State Univ, Coll Med, Dept Med, Hershey, PA 17033 USA

来源：

SCIENCE | 2008年 / 322卷 / 5907期

关键词：

D O I：

10.1126/science.1160794

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

A high-fat diet causes activation of the regulatory protein c-Jun NH(2)-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is therefore a potential target for therapeutic treatment of metabolic syndrome. We explored the mechanism of JNK1 signaling by engineering mice in which the Jnk1 gene was ablated selectively in adipose tissue. JNK1 deficiency in adipose tissue suppressed high- fat diet- induced insulin resistance in the liver. JNK1- dependent secretion of the inflammatory cytokine interleukin- 6 by adipose tissue caused increased expression of liver SOCS3, a protein that induces hepatic insulin resistance. Thus, JNK1 activation in adipose tissue can cause insulin resistance in the liver.

引用

页码：1539 / 1543

页数：5

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