Targeting of microRNAs for therapeutics

被引：40

作者：

Stenvang, Jan ^{[1
,2
]}

Lindow, Morten ^{[1
]}

Kauppinen, Sakari ^{[1
,2
]}

机构：

[1] Santaris Pharma, DK-2970 Horsholm, Denmark

[2] Univ Copenhagen, Dept Cellular & Mol Med, Wilhelm Johannsen Ctr Funct Genome Res, DK-2200 Copenhagen, Denmark

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

antisense; locked nucleic acid (LNA); microRNA (miRNA); non-coding RNA; therapeutic;

D O I：

10.1042/BST0361197

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

miRNAs (microRNAs) comprise a class of small endogenous non-coding RNAs that post-transcriptionally repress gene expression by base-pairing with their target mRNAs. Recent evidence has shown that miRNAs play important roles in a wide variety of human diseases, such as viral infections, cancer and cardiovascular diseases, and thus miRNAs have rapidly emerged as potential targets for therapeutics. LNAs (locked nucleic acids) comprise a class of bicyclic conformational analogues of RNA, which exhibit high binding affinity to complementary RNA molecules and high stability in blood and tissues in vivo. Recent reports on LNA-mediated miRNA silencing in rodents and primates support the potential of LNA-modified oligonucleotides in studying miRNA functions in vivo and in the future development of miRNA-based therapeutics.

引用

收藏

页码：1197 / 1200

页数：4

相关论文

共 36 条

[1] The impact of microRNAs on protein output [J].

Baek, Daehyun ;

Villen, Judit ;

Shin, Chanseok ;

Camargo, Fernando D. ;

Gygi, Steven P. ;

Bartel, David P. .

NATURE, 2008, 455 (7209) :64-U38

[2] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[3] Principles of MicroRNA-target recognition [J].

Brennecke, J ;

Stark, A ;

Russell, RB ;

Cohen, SM .

PLOS BIOLOGY, 2005, 3 (03) :404-418

[4] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[5] Liver-specific MicroRNA miR-122 enhances the replication of hepatitis C virus in nonhepatic cells [J].

Chang, Jinhong ;

Cruo, Ju-Tao ;

Jiang, Dong ;

Guo, Haitao ;

Taylor, John M. ;

Block, Timothy M. .

JOURNAL OF VIROLOGY, 2008, 82 (16) :8215-8223

[6]

Chang Jinhong, 2004, RNA Biol, V1, P106, DOI 10.4161/rna.1.2.1066

[7] TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing [J].

Chendrimada, TP ;

Gregory, RI ;

Kumaraswamy, E ;

Norman, J ;

Cooch, N ;

Nishikura, K ;

Shiekhattar, R .

NATURE, 2005, 436 (7051) :740-744

[8] Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice [J].

Costinean, S ;

Zanesi, N ;

Pekarsky, Y ;

Tili, E ;

Volinia, S ;

Heerema, N ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7024-7029

[9] Improved targeting of miRNA with antisense oligonucleotides [J].

Davis, Scott ;

Lollo, Bridget ;

Freier, Susan ;

Esau, Christine .

NUCLEIC ACIDS RESEARCH, 2006, 34 (08) :2294-2304

[10] LNA-mediated microRNA silencing in non-human primates [J].

Elmen, Joacim ;

Lindow, Morten ;

Schutz, Sylvia ;

Lawrence, Matthew ;

Petri, Andreas ;

Obad, Susanna ;

Lindholm, Marie ;

Hedtjarn, Maj ;

Hansen, Henrik Frydenlund ;

Berger, Urs ;

Gullans, Steven ;

Kearney, Phil ;

Sarnow, Peter ;

Straarup, Ellen Marie ;

Kauppinen, Sakari .

NATURE, 2008, 452 (7189) :896-U10

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