The SCF ubiquitin ligase: An extended look

被引：134

作者：

Jackson, PK ^{[1
]}

Eldridge, AG ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Palo Alto, CA 94305 USA

来源：

MOLECULAR CELL | 2002年 / 9卷 / 05期

关键词：

D O I：

10.1016/S1097-2765(02)00538-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The SCF E3 ubiquitin ligases select specific proteins for ubiquitination (and typically destruction) by coupling variable adaptor (F box) proteins that bind protein substrates to a conserved catalytic engine containing a cullin, Cul1, and the Rbx1/Roc1 RING finger protein. A new crystal structure of the SCFSkp2 ubiquitin ligase shows the molecular organization of this complex and raises important questions as to how substrate ubiquitination is accomplished.

引用

页码：923 / 925

页数：3

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