The enigmatic role of Sir2 in aging

被引：43

作者：

Kennedy, BK ^{[1
]}

Smith, ED

Kaeberlein, M

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci & Med, Seattle, WA 98195 USA

来源：

CELL | 2005年 / 123卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.11.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this issue of Cell, Longo and colleagues (Fabrizio et al., 2005) examine the role of Sir2, a histone deacetylase, in chronological aging in yeast by measuring the long-term survival of nondividing cells. In contrast to measurements of aging for mitotic cells, cell survival in the nonmitotic state is decreased by Sir2 activity under conditions that mimic calorie restriction.

引用

收藏

页码：548 / 550

页数：3

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