Stereospecific β-lithiation of oxazolinyloxiranes:: Synthesis of α,β-epoxy-γ-butyrolactones

被引：43

作者：

Capriati, V ^{[1
]}

Degennaro, L ^{[1
]}

Favia, R ^{[1
]}

Florio, S ^{[1
]}

Luisi, R ^{[1
]}

机构：

[1] Univ Bari, Dipartimento Farmaco Chim, ICCOM, I-70125 Bari, Italy

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 09期

关键词：

D O I：

10.1021/ol025781i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific beta-lithlation of beta-aryl-substituted oxazollnyloxiranes is described. The trapping reaction of such reactive intermediates with carbonyl compounds gave alpha,beta-epoxy-gamma-butyrolactones after deblocking of the oxazoline moiety. This methodology has been also extended to the synthesis of optically active alpha,beta-epoxy-gamma-butyrolactones.

引用

收藏

页码：1551 / 1554

页数：4

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