Microwave-assisted oxidative aromatization of Hantzsch 1,4-dihydropyridines using manganese dioxide

被引：83

作者：

Bagley, MC ^{[1
]}

Lubinu, MC ^{[1
]}

机构：

[1] Univ Cardiff Wales, Sch Chem, Cardiff CF10 3AT, Wales

来源：

SYNTHESIS-STUTTGART | 2006年 / 08期

关键词：

aromatization; Hantzsch dihydropyridines; heterocycles; microwave synthesis; oxidation;

D O I：

10.1055/s-2006-926407

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Aryl- and 4-alkyl-1,4-dihydropyridines, prepared by microwave-assisted Hantzsch reaction, are readily and efficiently aromatized in only one minute using commercial manganese dioxide in the absence of an inorganic support at 100 degrees C under microwave irradiation. This rapid procedure is more efficient than microwave-assisted arornatization using Pd/C, iodine or o-iodoxy-benzoic acid (IBX) and gives the dehydrogenated or 4-dealkylated product in 91-100% yield (13 examples).

引用

页码：1283 / 1288

页数：6

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