Colon cancer and apoptosis

被引：141

作者：

Huerta, S ^{[1
]}

Goulet, EJ ^{[1
]}

Livingston, EH ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Gastrointestinal & Endocrine Surg, Vet Adm N Texas Hlth Care Syst, Dallas, TX 75216 USA

来源：

AMERICAN JOURNAL OF SURGERY | 2006年 / 191卷 / 04期

关键词：

caspase; Smac/DIABLO; IAPs; c-FLIP; BAX; TRAIL; p53; apc; fas; Bcl-2; Bcl-xL; Bak; NF kappa B; survivin;

D O I：

10.1016/j.amjsurg.2005.11.009

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: The implementation of new therapeutic options for the management of metastatic colon cancer mandates a revisit to apoptosis and its role in colon cancer tumorigenesis with an emphasis on the mechanisms leading to chemotherapeutic resistance and immune system evasion of colon cancer cells. Data sources: Literature regarding molecular apoptosis mechanisms and the role of apoptosis in colon cancer progression are reviewed by this article. Conclusion: Programmed cell death has rapidly emerged as a potential target for cancer treatment at various stages of tumor progression. Chemoprevention, immuno-regulation. and metastasis are prospective targets by which apoptotic mechanisms could be utilized in the prevention and management of tumorigenesis. Understanding how defects in the death receptor pathway of apoptosis permit colon cancer cells to escape the immune system Would allow for treatment options whereby the body's immune system could again recognize and eliminate unwanted cells. (c) 2006 Excerpta Medica Inc. All rights reserved.

引用

页码：517 / 526

页数：10

共 105 条

[1] The mitochondrial apoptosome: a killer unleashed by the cytochrome seas [J].

Adrain, C ;

Martin, SJ .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (06) :390-397

[2] Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas [J].

Anti, M ;

Armuzzi, A ;

Morini, S ;

Iascone, E ;

Pignataro, G ;

Coco, C ;

Lorenzetti, R ;

Paolucci, M ;

Covino, M ;

Gasbarrini, A ;

Vecchio, FM ;

Gasbarrini, G .

GUT, 2001, 48 (02) :238-246

[3] Differential expression of cell cycle and apoptosis related proteins in colorectal mucosa, primary colon tumours, and liver metastases [J].

Backus, HHJ ;

Van Groeningen, CJ ;

Vos, W ;

Dukers, DF ;

Bloemena, E ;

Wouters, D ;

Pinedo, HM ;

Peters, GJ .

JOURNAL OF CLINICAL PATHOLOGY, 2002, 55 (03) :206-211

[4] Stress signals for apoptosis: ceramide and c-Jun kinase [J].

Basu, S ;

Kolesnick, R .

ONCOGENE, 1998, 17 (25) :3277-3285

[5]

BEDI A, 1995, CANCER RES, V55, P1811

[6] Apoptosis without caspases: an inefficient molecular guillotine? [J].

Borner, C ;

Monney, L .

CELL DEATH AND DIFFERENTIATION, 1999, 6 (06) :497-507

[7] Cell death independent of caspases:: A review [J].

Bröker, LE ;

Kruyt, FAE ;

Giaccone, G .

CLINICAL CANCER RESEARCH, 2005, 11 (09) :3155-3162

[8] Deregulation of apoptosis in colorectal carcinoma: Theoretical and therapeutic implications [J].

Butler, LM ;

Hewett, PJ ;

Fitridge, RA ;

Cowled, PA .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 1999, 69 (02) :88-94

[9] Apaf-1/cytochrome c-independent and Smac-dependent induction of apoptosis in multiple myeloma (MM) cells [J].

Chauhan, D ;

Hideshima, T ;

Rosen, S ;

Reed, JC ;

Kharbanda, S ;

Anderson, KC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (27) :24453-24456

[10] Apoptosis [J].

Cummings, MC ;

Winterford, CM ;

Walker, NI .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1997, 21 (01) :88-101

← 1 2 3 4 5 6 7 8 9 10 →