GeneMANIA Prediction Server 2013 Update

被引：315

作者：

Zuberi, Khalid ^{[1
]}

Franz, Max ^{[1
]}

Rodriguez, Harold ^{[1
]}

Montojo, Jason ^{[1
]}

Lopes, Christian Tannus ^{[1
]}

Bader, Gary D. ^{[1
,2
,3
]}

Morris, Quaid ^{[1
,2
,3
,4
]}

机构：

[1] Univ Toronto, Donnelly Ctr, Toronto, ON M5S 1A1, Canada

[2] Univ Toronto, Dept Comp Sci, Toronto, ON M5S 1A1, Canada

[3] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

[4] Univ Toronto, Dept Elect & Comp Engn, Toronto, ON M5S 1A1, Canada

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / W1期

关键词：

GENE-FUNCTION; INTERACTION DATABASE; NETWORK; INTEGRATION; EXPRESSION; RESOURCE;

D O I：

10.1093/nar/gkt533

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

GeneMANIA (http://www.genemania.org) is a flexible user-friendly web interface for generating hypotheses about gene function, analyzing gene lists and prioritizing genes for functional assays. Given a query gene list, GeneMANIA extends the list with functionally similar genes that it identifies using available genomics and proteomics data. GeneMANIA also reports weights that indicate the predictive value of each selected data set for the query. GeneMANIA can also be used in a function prediction setting: given a query gene, GeneMANIA finds a small set of genes that are most likely to share function with that gene based on their interactions with it. Enriched Gene Ontology categories among this set can sometimes point to the function of the gene. Seven organisms are currently supported (Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Homo sapiens, Rattus norvegicus and Saccharomyces cerevisiae), and hundreds of data sets have been collected from GEO, BioGRID, IRefIndex and I2D, as well as organism-specific functional genomics data sets. Users can customize their search by selecting specific data sets to query and by uploading their own data sets to analyze.

引用

页码：W115 / W122

页数：8

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