Comparative interactomics with Funcoup 2.0

被引：39

作者：

Alexeyenko, Andrey ^{[1
,2
]}

Schmitt, Thomas ^{[1
,3
,4
]}

Tjarnberg, Andreas ^{[1
,3
,4
]}

Guala, Dmitri ^{[1
,3
,4
]}

Frings, Oliver ^{[1
,3
,4
]}

Sonnhammer, Erik L. L. ^{[1
,3
,4
]}

机构：

[1] Sci Life Lab, SE-17121 Solna, Sweden

[2] Royal Inst Technol, Sch Biotechnol, SE-17121 Solna, Sweden

[3] Stockholm Univ, Stockholm Bioinformat Ctr, Stockholm, Sweden

[4] Stockholm Univ, Dept Biochem & Biophys, Stockholm, Sweden

来源：

NUCLEIC ACIDS RESEARCH | 2012年 / 40卷 / D1期

基金：

瑞典研究理事会;

关键词：

DATABASE; ALIGNMENT; NETWORKS; SERVER; GENES;

D O I：

10.1093/nar/gkr1062

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

FunCoup (http://FunCoup.sbc.su.se) is a database that maintains and visualizes global gene/protein networks of functional coupling that have been constructed by Bayesian integration of diverse high-throughput data. FunCoup achieves high coverage by orthology-based integration of data sources from different model organisms and from different platforms. We here present release 2.0 in which the data sources have been updated and the methodology has been refined. It contains a new data type Genetic Interaction, and three new species: chicken, dog and zebra fish. As FunCoup extensively transfers functional coupling information between species, the new input datasets have considerably improved both coverage and quality of the networks. The number of high-confidence network links has increased dramatically. For instance, the human network has more than eight times as many links above confidence 0.5 as the previous release. FunCoup provides facilities for analysing the conservation of subnetworks in multiple species. We here explain how to do comparative interactomics on the FunCoup website.

引用

页码：D821 / D828

页数：8

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