Comparative analysis and unification of domain-domain interaction networks

被引：20

作者：

Bjorkholm, Patrik ^{[1
]}

Sonnhammer, Erik L. L. ^{[1
]}

机构：

[1] Stockholm Univ, Stockholm Bioinformat Ctr, S-10691 Stockholm, Sweden

来源：

BIOINFORMATICS | 2009年 / 25卷 / 22期

基金：

瑞典研究理事会;

关键词：

PROTEIN-PROTEIN INTERACTIONS; DATABASE; PREDICTION; GENOME;

D O I：

10.1093/bioinformatics/btp522

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Motivation: Certain protein domains are known to preferentially interact with other domains. Several approaches have been proposed to predict domain-domain interactions, and over nine datasets are available. Our aim is to analyse the coverage and quality of the existing resources, as well as the extent of their overlap. With this knowledge, we have the opportunity to merge individual domain interaction networks to construct a comprehensive and reliable database. Results: In this article we introduce a new approach towards comparing domain-domain interaction networks. This approach is used to compare nine predicted domain and protein interaction networks. The networks were used to generate a database of unified domain interactions, UniDomInt. Each interaction in the dataset is scored according to the benchmarked reliability of the sources. The performance of UniDomInt is an improvement compared to the underlying source networks and to another composite resource, Domine.

引用

页码：3020 / 3025

页数：6

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