The causes and consequences of genetic heterogeneity in cancer evolution

被引：1672

作者：

Burrell, Rebecca A. ^{[1
]}

McGranahan, Nicholas ^{[1
,2
]}

Bartek, Jiri ^{[3
,4
]}

Swanton, Charles ^{[1
,5
]}

机构：

[1] Canc Res UK London Res Inst, Translat Canc Therapeut Lab, London WC2A 3LY, England

[2] UCL, Ctr Math & Phys Life Sci & Expt Biol CoMPLEX, London WC1E 6BT, England

[3] Danish Canc Soc, Res Ctr, DK-2100 Copenhagen, Denmark

[4] Palacky Univ, Inst Mol & Translat Med, CZ-77515 Olomouc, Czech Republic

[5] UCL Canc Inst, London WC1E 6BT, England

来源：

NATURE | 2013年 / 501卷 / 7467期

基金：

英国医学研究理事会;

关键词：

CHROMOSOME SEGREGATION ERRORS; INTRA-TUMOR HETEROGENEITY; DNA-DAMAGE RESPONSE; MUTATIONAL PROCESSES; CLONAL EVOLUTION; BREAST-CANCER; COLON-CANCER; GENOMIC INSTABILITY; COLORECTAL ADENOMAS; REPLICATION STRESS;

D O I：

10.1038/nature12625

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.

引用

页码：338 / 345

页数：8

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