The causes and consequences of genetic heterogeneity in cancer evolution

被引:1672
作者
Burrell, Rebecca A. [1 ]
McGranahan, Nicholas [1 ,2 ]
Bartek, Jiri [3 ,4 ]
Swanton, Charles [1 ,5 ]
机构
[1] Canc Res UK London Res Inst, Translat Canc Therapeut Lab, London WC2A 3LY, England
[2] UCL, Ctr Math & Phys Life Sci & Expt Biol CoMPLEX, London WC1E 6BT, England
[3] Danish Canc Soc, Res Ctr, DK-2100 Copenhagen, Denmark
[4] Palacky Univ, Inst Mol & Translat Med, CZ-77515 Olomouc, Czech Republic
[5] UCL Canc Inst, London WC1E 6BT, England
基金
英国医学研究理事会;
关键词
CHROMOSOME SEGREGATION ERRORS; INTRA-TUMOR HETEROGENEITY; DNA-DAMAGE RESPONSE; MUTATIONAL PROCESSES; CLONAL EVOLUTION; BREAST-CANCER; COLON-CANCER; GENOMIC INSTABILITY; COLORECTAL ADENOMAS; REPLICATION STRESS;
D O I
10.1038/nature12625
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent studies have revealed extensive genetic diversity both between and within tumours. This heterogeneity affects key cancer pathways, driving phenotypic variation, and poses a significant challenge to personalized cancer medicine. A major cause of genetic heterogeneity in cancer is genomic instability. This instability leads to an increased mutation rate and can shape the evolution of the cancer genome through a plethora of mechanisms. By understanding these mechanisms we can gain insight into the common pathways of tumour evolution that could support the development of future therapeutic strategies.
引用
收藏
页码:338 / 345
页数:8
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