Of cancer and cave fish

被引：74

作者：

Gatenby, Robert A. ^{[1
,2
]}

Gillies, Robert J. ^{[1
,2
]}

Brown, Joel S. ^{[3
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Tampa, FL 33612 USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Tampa, FL 33612 USA

[3] Univ Illinois, Dept Biol Sci, Chicago, IL 60607 USA

来源：

NATURE REVIEWS CANCER | 2011年 / 11卷 / 04期

关键词：

REGRESSIVE EVOLUTION; ADAPTATIONS; SYSTEMS;

D O I：

10.1038/nrc3036

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We propose that the drivers of carcinogenesis lie more in the adaptive changes that are enabled by local or systemic alterations of tissue architecture than in the genetic changes observed in cancer cells. A full understanding of cancer biology and therapy through a cataloguing of the cancer genome is unlikely unless it is integrated into an evolutionary and ecological context. © 2011 Macmillan Publishers Limited. All rights reserved.

引用

页码：237 / 238

页数：2

共 14 条

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