The evolutionary dynamics of cancer prevention

被引：61

作者：

Gatenby, Robert A. ^{[1
,2
]}

Gillies, Robert J. ^{[1
,2
]}

Brown, Joel S. ^{[3
]}

机构：

[1] H Lee Moffitt Canc Ctr & Res Inst, Dept Radiol, Moffett Field, CA USA

[2] H Lee Moffitt Canc Ctr & Res Inst, Dept Integrated Math Oncol, Moffett Field, CA USA

[3] Univ Illinois, Dept Biol Sci, Chicago, IL 60680 USA

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 08期

关键词：

D O I：

10.1038/nrc2892

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multicellular organisms must evolve mechanisms to suppress cancer formation prior to reproduction, and we propose that the organizational structure of normal epithelium is one such strategy. Understanding evolved host cancer suppression mechanisms is essential to defining the first steps of carcinogenesis and developing rational cancer prevention strategies.

引用

页码：526 / 527

页数：2