Causes and consequences of aneuploidy in cancer

被引：615

作者：

Gordon, David J. ^{[1
]}

Resio, Benjamin ^{[1
]}

Pellman, David ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; MEROTELIC KINETOCHORE ORIENTATION; RETINOBLASTOMA TUMOR-SUPPRESSOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; MEDIATED CHROMOSOME TRANSFER; DOSAGE LETHAL SCREENS; GENETIC INSTABILITY; COLORECTAL CANCERS; DOWN-SYNDROME; HUMAN-CELLS;

D O I：

10.1038/nrg3123

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic instability, which includes both numerical and structural chromosomal abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements have received substantial attention, the role of whole-chromosome aneuploidy in cancer is much less well-understood. Here we review recent progress in understanding the roles of whole-chromosome aneuploidy in cancer, including the mechanistic causes of aneuploidy, the cellular responses to chromosome gains or losses and how cells might adapt to tolerate these usually detrimental alterations. We also explore the role of aneuploidy in cellular transformation and discuss the possibility of developing aneuploidy-specific therapies.

引用

页码：189 / 203

页数：15

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