Causes and consequences of aneuploidy in cancer

被引：615

作者：

Gordon, David J. ^{[1
]}

Resio, Benjamin ^{[1
]}

Pellman, David ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

来源：

NATURE REVIEWS GENETICS | 2012年 / 13卷 / 03期

关键词：

ACUTE MYELOID-LEUKEMIA; MEROTELIC KINETOCHORE ORIENTATION; RETINOBLASTOMA TUMOR-SUPPRESSOR; ACUTE LYMPHOBLASTIC-LEUKEMIA; MEDIATED CHROMOSOME TRANSFER; DOSAGE LETHAL SCREENS; GENETIC INSTABILITY; COLORECTAL CANCERS; DOWN-SYNDROME; HUMAN-CELLS;

D O I：

10.1038/nrg3123

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic instability, which includes both numerical and structural chromosomal abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements have received substantial attention, the role of whole-chromosome aneuploidy in cancer is much less well-understood. Here we review recent progress in understanding the roles of whole-chromosome aneuploidy in cancer, including the mechanistic causes of aneuploidy, the cellular responses to chromosome gains or losses and how cells might adapt to tolerate these usually detrimental alterations. We also explore the role of aneuploidy in cellular transformation and discuss the possibility of developing aneuploidy-specific therapies.

引用

页码：189 / 203

页数：15

共 123 条

[41] Molecular analysis of the mitotic checkpoint genes BUB1, BUBR1 and BUB3 in human lung cancers [J].

Haruki, N ;

Saito, H ;

Harano, T ;

Nomoto, S ;

Takahashi, T ;

Osada, H ;

Fujii, Y ;

Takahashi, T .

CANCER LETTERS, 2001, 162 (02) :201-205

[42] Combined BubR1 protein down-regulation and RASSF1A hypermethylation in Wilms tumors with diverse cytogenetic changes [J].

Haruta, Masayuki ;

Matsumoto, Yoshiyuki ;

Izumi, Hideki ;

Watanabe, Naoki ;

Fukuzawa, Masahiro ;

Matsuura, Shinya ;

Kaneko, Yasuhiko .

MOLECULAR CARCINOGENESIS, 2008, 47 (09) :660-666

[43] Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis [J].

Holland, Andrew J. ;

Cleveland, Don W. .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (07) :478-487

[44] Widespread aneuploidy revealed by DNA microarray expression profiling [J].

Hughes, TR ;

Roberts, CJ ;

Dai, HY ;

Jones, AR ;

Meyer, MR ;

Slade, D ;

Burchard, J ;

Dow, S ;

Ward, TR ;

Kidd, MJ ;

Friend, SH ;

Marton, MJ .

NATURE GENETICS, 2000, 25 (03) :333-337

[45] Aneuploid neurons are functionally active and integrated into brain circuitry [J].

Kingsbury, MA ;

Friedman, B ;

McConnell, MJ ;

Rehen, SK ;

Yang, AH ;

Kaushal, D ;

Chun, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (17) :6143-6147

[46]

Knudsen ES, 2006, CURR MOL MED, V6, P749

[47] On the road to cancer: Aneuploidy and the mitotic checkpoint [J].

Kops, GJPL ;

Weaver, BAA ;

Cleveland, DW .

NATURE REVIEWS CANCER, 2005, 5 (10) :773-785

[48] Centrosome clustering and chromosomal (in)stability: A matter of life and death [J].

Kraemer, Alwin ;

Maier, Bettina ;

Bartek, Jiri .

MOLECULAR ONCOLOGY, 2011, 5 (04) :324-335

[49] Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes [J].

Kwon, Mijung ;

Godinho, Susana A. ;

Chandhok, Namrata S. ;

Ganem, Neil J. ;

Azioune, Ammar ;

Thery, Manuel ;

Pellman, David .

GENES & DEVELOPMENT, 2008, 22 (16) :2189-2203

[50]

Langabeer SE, 2003, LEUKEMIA, V17, P1915, DOI 10.1038/sj.leu.2403066

← 1 2 3 4 5 6 7 8 9 10 →