Expression of estrogen receptor-beta in human breast tumors

被引：198

作者：

Dotzlaw, H

Leygue, E

Watson, PH

Murphy, LC

机构：

[1] UNIV MANITOBA, DEPT BIOCHEM & MOL BIOL, WINNIPEG, MB R3E 0W3, CANADA

[2] UNIV MANITOBA, DEPT PATHOL, WINNIPEG, MB R3E 0W3, CANADA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1997年 / 82卷 / 07期

关键词：

D O I：

10.1210/jc.82.7.2371

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The expression of a recently described novel estrogen receptor, ER-beta, was detected in several human breast tumor biopsy samples and several human breast epithelial cell lines using reverse transcription and polymerase chain reaction (RT-PCR) analysis. Cloning and sequencing of the PCR product from a breast tumor confirmed the identity of the sequence with that of the ER-beta mRNA previously reported in human testis. The expression of ER-beta was not correlated with that of ER-alpha, and both ER-alpha positive and ER-alpha negative cell lines expressed ER-beta mRNA. However, some breast tumors and some cell lines coexpress ER-beta and ER-alpha mRNA. Our data support a possible role for ER-beta in human breast cancer.

引用

页码：2371 / 2374

页数：4