Targeting antioxidants to mitochondria: A new therapeutic direction

被引：348

作者：

Sheu, SS

Nauduri, D

Anders, MW

机构：

[1] Univ Rochester, Med Ctr, Dept Anesthesiol, Rochester, NY 14642 USA

[2] Univ Rochester, Med Ctr, Mitochondrial Res Interest Grp, Rochester, NY 14642 USA

[3] Univ Rochester, Med Ctr, Dept Physiol & Pharmacol, Rochester, NY 14642 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2006年 / 1762卷 / 02期

关键词：

reactive oxygen species; antioxidant; mitochondria; mitochondria membrane potential; oxidative stress;

D O I：

10.1016/j.bbadis.2005.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria play an important role in controlling the life and death of a cell. Consequently, mitochondrial dysfunction leads to a range of human diseases such as ischemia-reperfusion injury, sepsis, and diabetes. Although the molecular mechanisms responsible for mitochondria-mediated disease processes are not fully elucidated yet, the oxidative stress appears to be critical. Accordingly, strategies are being developed for the targeted delivery of antioxidants to mitochondria. In this review, we shall briefly discuss cellular reactive oxygen species metabolism and its role in pathophysiology; the currently existing antioxidants and possible reasons why they are not effective in ameliorating oxidative stress-mediated diseases; and recent developments in mitochondrially targeted antioxidants and their future promise for disease treatment. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：256 / 265

页数：10

共 63 条

[21] Antioxidant treatment of patients with Friedreich ataxia - Four-year follow-up [J].