Lipase-catalysed regioselective deacetylation of androstane derivatives

被引：29

作者：

Baldessari, A ^{[1
]}

Bruttomesso, AC ^{[1
]}

Gros, EG ^{[1
]}

机构：

[1] UNIV BUENOS AIRES,FAC CIENCIAS EXACTAS & NAT,DEPT QUIM ORGAN,RA-1428 BUENOS AIRES,DF,ARGENTINA

来源：

HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 04期

关键词：

D O I：

10.1002/hlca.19960790408

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of acetoxy derivatives of androstane was deacetylated in organic solvents by several lipases. The most satisfactory results were obtained with lipase from Candida cylindracea (CCL) and Candida antarctica (GAL). In some derivatives, CCL and CAL showed an overwhelming regioselectivity towards the removal of the 3 beta- or the 17 beta-acetyl group (see Table 2). Three new steroid derivatives were obtained through this approach. A hypothetical rationale for the behaviour of these enzymes is given.

引用

页码：999 / 1004

页数：6

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