Prenatal testosterone excess programs reproductive and metabolic dysfunction in the female

被引：97

作者：

Padmanabhan, V ^{[1
]}

Manikkam, M

Recabarren, S

Foster, D

机构：

[1] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI USA

[3] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI USA

[4] Univ Michigan, Dep Mol & Integrat Physiol, Ann Arbor, MI USA

[5] Univ Michigan, Dept Ecol & Evolutionary Biol, Ann Arbor, MI USA

[6] Univ Michigan, Reprod Sci Program, Ann Arbor, MI 48109 USA

[7] Univ Concepcion, Fac Med Vet, Lab Anim Physiol & Endocrinol, Concepcion, Chile

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2006年 / 246卷 / 1-2期

关键词：

steroids; fetal programming; ovary; neuroendocrine; fertility; growth; IUGR; sheep;

D O I：

10.1016/j.mce.2005.11.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Findings discussed in this review stress the importance of normal estrogen and androgen signaling at appropriate developmental time points in maintaining normal phenotypic expression, reproductive and metabolic function and document how inappropriate steroid signaling, at inopportune times can have undesirable outcomes. For example, inappropriate testosterone exposure during fetal life alters the developmental trajectory of the female culminating in a suite of disorders, which include intrauterine growth-retardation and postnatal catch up growth, phenotypic masculinization, reproductive neuroendocrine and ovarian disruptions leading to progressive loss of cyclicity and metabolic disruptions manifested as hyperinsulinemia. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：165 / 174

页数：10

相关论文

共 105 条

[1] Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys [J].

Abbott, DH ;

Dumesic, DA ;

Eisner, JR ;

Colman, RJ ;

Kemnitz, JW .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (02) :62-67

[2] Oestradiol microimplants in the ventromedial preoptic area inhibit secretion of luteinizing hormone via dopamine neurones in anoestrous ewes [J].

Anderson, GM ;

Connors, JM ;

Hardy, SL ;

Valent, M ;

Goodman, RL .

JOURNAL OF NEUROENDOCRINOLOGY, 2001, 13 (12) :1051-1058

[3] How possible is the prevention of polycystic ovary syndrome development in adolescent patients with early onset of hyperandrogenism [J].

Apter, D .

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1998, 21 (09) :613-617

[4] Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, sertoli cell number, and the efficiency of spermatogenesis in adulthood [J].

Atanassova, N ;

McKinnell, C ;

Walker, M ;

Turner, KJ ;

Fisher, JS ;

Morley, M ;

Millar, MR ;

Groome, NP ;

Sharpe, RM .

ENDOCRINOLOGY, 1999, 140 (11) :5364-5373

[5] OVARIAN HYPERANDROGYNISM AS A RESULT OF CONGENITAL ADRENAL VIRILIZING DISORDERS - EVIDENCE FOR PERINATAL MASCULINIZATION OF NEUROENDOCRINE FUNCTION IN WOMEN [J].

BARNES, RB ;

ROSENFIELD, RL ;

EHRMANN, DA ;

CARA, JF ;

CUTTLER, L ;

LEVITSKY, LL ;

ROSENTHAL, IM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (05) :1328-1333

[6] TOWARD PHYSIOLOGICAL UNDERSTANDING OF GLUCOSE-TOLERANCE - MINIMAL-MODEL APPROACH [J].

BERGMAN, RN .

DIABETES, 1989, 38 (12) :1512-1527

[7] The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men [J].

Bhasin, S ;

Storer, TW ;

Berman, N ;

Callegari, C ;

Clevenger, B ;

Phillips, J ;

Bunnell, TJ ;

Tricker, R ;

Shirazi, A ;

Casaburi, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (01) :1-7

[8] Prenatal programming of reproductive neuroendocrine function: Fetal androgen exposure produces progressive disruption of reproductive cycles in sheep [J].

Birch, RA ;

Padmanabhan, V ;

Foster, DL ;

Unsworth, WP ;

Robinson, JE .

ENDOCRINOLOGY, 2003, 144 (04) :1426-1434

[9] Mechanisms of estrogen receptor signaling:: Convergence of genomic and nongenomic actions on target genes [J].

Björnström, L ;

Sjöberg, M .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (04) :833-842

[10] In utero diethylstilbestrol (DES) exposure alters Hox gene expression in the developing mullerian system [J].

Block, K ;

Kardana, A ;

Igarashi, P ;

Taylor, HS .

FASEB JOURNAL, 2000, 14 (09) :1101-1108

← 1 2 3 4 5 6 7 8 9 10 →