Synthesis of enantiomerically pure 9-[(1′R,2′R,3′S)-bis(hydroxymethyl)thietan-1′-yl] adenine, 3′-thio analog of oxetanocin A

被引：18

作者：

Ichikawa, E

Yamamura, S

Kato, K ^{[1
]}

机构：

[1] Nippon Kayaku Co Ltd, Pharmaceut Grp, Res Labs, Kita Ku, Tokyo 115, Japan

[2] Keio Univ, Fac Sci & Technol, Dept Chem, Yokohama, Kanagawa 223, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 41期

关键词：

nucleosides; Pummerer reactions; thietanes;

D O I：

10.1016/S0040-4039(99)01515-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantiomerically pure synthesis of9-[(1'R,2'R,3'S)-bis(hydroxymethyl)thietan-1'-yl]adenine 2, 3'-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et3N under the Pummerer reaction conditions. (C) 1999 Elsevier Science Ltd. AII rights reserved.

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页码：7385 / 7388

页数：4

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