Development of Tools to Study Lacto-N-Biosidase: An Important Enzyme Involved in the Breakdown of Human Milk Oligosaccharides

被引:6
作者
Hattie, Mitchell [1 ]
Debowski, Aleksandra W. [1 ]
Stubbs, Keith A. [1 ]
机构
[1] Univ Western Australia, Sch Chem & Biochem, Crawley, WA 6009, Australia
基金
澳大利亚研究理事会;
关键词
carbohydrates; enzymes; human milk oligosaccharides; inhibitors; lacto-N-biosidase; SUBSTRATE-ASSISTED CATALYSIS; SEQUENCE-BASED CLASSIFICATION; TRANSITION-STATE; FED INFANTS; NEUTRAL OLIGOSACCHARIDES; GLYCOSIDE HYDROLASES; STRUCTURAL INSIGHTS; INTESTINAL FLORA; MECHANISM; BIFIDOBACTERIUM;
D O I
10.1002/cbic.201200135
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:1128 / 1131
页数:4
相关论文
共 55 条
[21]   Kinetic evidence related to substrate-assisted catalysis of family 18 chitinases [J].
Honda, Y ;
Kitaoka, M ;
Hayashi, K .
FEBS LETTERS, 2004, 567 (2-3) :307-310
[22]   In vitro Th1 cytokine-independent Th2 suppressive effects of bifidobacteria [J].
Iwabuchi, Noriyuki ;
Takahashi, Noritoshi ;
Xiao, Jin-zhong ;
Miyaji, Kazuhiro ;
Iwatsuki, Keiji .
MICROBIOLOGY AND IMMUNOLOGY, 2007, 51 (07) :649-660
[23]  
JONES CS, 1980, J BIOL CHEM, V255, P1861
[24]   Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum [J].
Kitaoka, M ;
Tian, JS ;
Nishimoto, M .
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2005, 71 (06) :3158-3162
[25]   NAG-thiazoline, an N-acetyl-beta-hexosaminidase inhibitor that implicates acetamido participation [J].
Knapp, S ;
Vocadlo, D ;
Gao, ZN ;
Kirk, B ;
Lou, JP ;
Withers, SG .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (28) :6804-6805
[26]   Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides:: More like breast-fed infants [J].
Knol, J ;
Scholtens, P ;
Kafka, C ;
Steenbakkers, J ;
Gross, S ;
Helm, K ;
Klarczyk, M ;
Schöpfer, H ;
Böckler, HM ;
Wells, J .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2005, 40 (01) :36-42
[27]  
KOBATA A, 1972, J BIOL CHEM, V247, P1525
[28]   Oligosaccharides in human milk: Structural, functional, and metabolic aspects [J].
Kunz, C ;
Rudloff, S ;
Baier, W ;
Klein, N ;
Strobel, S .
ANNUAL REVIEW OF NUTRITION, 2000, 20 :699-722
[29]   Structural basis of the conversion of T4 lysozyme into a transglycosidase by reengineering the active site [J].
Kuroki, R ;
Weaver, LH ;
Matthews, BW .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (16) :8949-8954
[30]   Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases [J].
Li C.M. ;
Tyler P.C. ;
Furneaux R.H. ;
Kicska G. ;
Xu Y. ;
Grubmeyer C. ;
Girvin M.E. ;
Schramm V.L. .
Nature Structural Biology, 1999, 6 (6) :582-587