Molecular genetics of early liver development

被引:83
作者
Zaret, KS
机构
[1] Dept. Molec. Biol., Cell Biol. B., Box G, Brown University, Providence
关键词
liver; development; transcription factor; gene regulation; transgenics;
D O I
10.1146/annurev.ph.58.030196.001311
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The control of liver development was originally defined by classical histology and tissue transplantation studies twenty to thirty years ago. In the past ten years, molecular biology studies have revealed numerous transcription factors important for adult liver differentiation. Recent work in which genes encoding regulatory proteins are inactivated in transgenic mice is evaluated in order to assess the consequences on liver development. The transgenic studies emphasize the roles of growth factors and signal transducers and the conservation of the basic components of signaling pathways in evolution.
引用
收藏
页码:231 / 251
页数:21
相关论文
共 131 条
  • [41] SUBLINES OF MOUSE 3T3 CELLS THAT ACCUMULATE LIPID
    GREEN, H
    KEHINDE, O
    [J]. CELL, 1974, 1 (03) : 113 - 116
  • [42] EPITHELIAL MORPHOGENESIS
    GUMBINER, BM
    [J]. CELL, 1992, 69 (03) : 385 - 387
  • [43] CLONING OF THE T-GENE REQUIRED IN MESODERM FORMATION IN THE MOUSE
    HERRMANN, BG
    LABEIT, S
    POUSTKA, A
    KING, TR
    LEHRACH, H
    [J]. NATURE, 1990, 343 (6259) : 617 - 622
  • [44] C-JUN IS ESSENTIAL FOR NORMAL MOUSE DEVELOPMENT AND HEPATOGENESIS
    HILBERG, F
    AGUZZI, A
    HOWELLS, N
    WAGNER, EF
    [J]. NATURE, 1993, 365 (6442) : 179 - 181
  • [45] DIFFERENTIATION OF THE MOUSE HEPATIC PRIMORDIUM .1. AN ANALYSIS OF TISSUE INTERACTIONS IN HEPATOCYTE DIFFERENTIATION
    HOUSSAINT, E
    [J]. CELL DIFFERENTIATION, 1980, 9 (05): : 269 - 279
  • [46] INDUCTION ACROSS GERM LAYERS IN DROSOPHILA MEDIATED BY A GENETIC CASCADE
    IMMERGLUCK, K
    LAWRENCE, PA
    BIENZ, M
    [J]. CELL, 1990, 62 (02) : 261 - 268
  • [47] EFFECTS OF AN RB MUTATION IN THE MOUSE
    JACKS, T
    FAZELI, A
    SCHMITT, EM
    BRONSON, RT
    GOODELL, MA
    WEINBERG, RA
    [J]. NATURE, 1992, 359 (6393) : 295 - 300
  • [48] ROLE OF STEM-CELL MIGRATION IN INITIATION OF MOUSE FETAL LIVER HEMATOPOIESIS
    JOHNSON, GR
    MOORE, MAS
    [J]. NATURE, 1975, 258 (5537) : 726 - 728
  • [49] JOHNSON GR, 1975, J EMBRYOL EXP MORPH, V30, P83
  • [50] JOHNSON PF, 1994, LIVER GENE EXPRESSIO, pCH12