Genetic single-nucleotide polymorphisms of inflammation-related factors associated with risk of lung cancer

被引：39

作者：

Bai, Lu ^{[1
]}

Yu, Hong ^{[2
]}

Wang, Hetong ^{[1
]}

Su, Hongxin ^{[1
]}

Zhao, Junhua ^{[3
]}

Zhao, Yuxia ^{[1
]}

机构：

[1] China Med Univ, Affiliated Hosp 1, Dept Radiat Oncol, Shenyang 110001, Peoples R China

[2] Liaoning Canc & Inst, Dept Radiat Oncol, Shenyang 110042, Peoples R China

[3] China Med Univ, Dept Year Clin 7, Shenyang 110001, Peoples R China

来源：

MEDICAL ONCOLOGY | 2013年 / 30卷 / 01期

关键词：

Lung cancer; Single-nucleotide polymorphism; Inflammation; Interleukin; 6; RECEPTOR SUBUNIT GENES; SUSCEPTIBILITY LOCUS; DNA-DAMAGE; EXPRESSION; INTERLEUKIN-6; ACTIVATION; PATHWAY; DISEASE; SMOKERS;

D O I：

10.1007/s12032-012-0414-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study was to investigate the association of inflammation-related factors with the risk of lung cancer. All subjects were unrelated ethnic Han Chinese in Liaoning province. Our study conducted a hospital-based case-control study, the case group consisted of 193 histologically diagnosed lung cancer patients, and 211 controls were selected from cancer-free patients at the same. 5 single-nucleotide polymorphisms (TGF beta 1 +869T/C, IL6 -634C/G, TGF beta 1 -509C/T, IL1 beta -511C/T, and IL1 alpha -899C/T) in inflammatory genes (IL1, IL6, TGF) were analyzed by Taqman real-time PCR method. All statistical analyses were performed with statistical product and service solutions v13.0. The genotype distribution frequency of IL6 -634C/G exists significant difference between case and control group. Individuals carrying -634GG and CG genotype had a higher risk of lung cancer. The risk allele was G in IL6 -634C/G.

引用

页数：5

共 24 条

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