TGFβ signaling in health and disease

被引：115

作者：

Akhurst, RJ ^{[1
]}

机构：

[1] Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 08期

关键词：

D O I：

10.1038/ng0804-790

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Inactivating mutations in TGFBR2, encoding the transforming growth factor-beta (TGFbeta) type 2 receptor, may account for up to 10% of cases of Marfan syndrome. This finding has implications for a wider spectrum of disorders, including cancer, fibrosis and inflammatory and cardiovascular diseases, which are influenced by TGFbeta.

引用

页码：790 / 792

页数：4

共 15 条

[1] Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia [J].

Abdalla, SA ;

Gallione, CJ ;

Barst, RJ ;

Horn, EM ;

Knowles, JA ;

Marchuk, DA ;

Letarte, M ;

Morse, JH .

EUROPEAN RESPIRATORY JOURNAL, 2004, 23 (03) :373-377

[2] Polymorphism R25P in the gene encoding transforming growth factor-beta (TGF-β1) is a newly identified risk factor for proliferative diabetic retinopathy [J].

Beránek, M ;

Kanková, K ;

Benes, P ;

Izakovicová-Hollá, L ;

Znojil, V ;

Hájek, D ;

Vlková, E ;

Vácha, J .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 109 (04) :278-283

[3] TGF-β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia [J].

Bhowmick, NA ;

Chytil, A ;

Plieth, D ;

Gorska, AE ;

Dumont, N ;

Shappell, S ;

Washington, MK ;

Neilson, EG ;

Moses, HL .

SCIENCE, 2004, 303 (5659) :848-851

[4] Polymorphisms of the transforming growth factor-beta 1 gene in relation to myocardial infarction and blood pressure - The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study [J].

Cambien, F ;

Ricard, S ;

Troesch, A ;

Mallet, C ;

Generenaz, L ;

Evans, A ;

Arveiler, D ;

Luc, G ;

Ruidavets, JB ;

Poirier, O .

HYPERTENSION, 1996, 28 (05) :881-887

[5] Analysis of transforming growth factor β1 gene polymorphisms in patients with systemic sclerosis [J].

Crilly, A ;

Hamilton, J ;

Clark, CJ ;

Jardine, A ;

Madhok, R .

ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (08) :678-681

[6] TGF-β signaling in tumor suppression and cancer progression [J].

Derynck, R ;

Akhurst, RJ ;

Balmain, A .

NATURE GENETICS, 2001, 29 (02) :117-129

[7] THE QUESTION OF HETEROGENEITY IN MARFAN-SYNDROME [J].

DIETZ, H ;

FRANCKE, U ;

FURTHMAYR, H ;

FRANCOMANO, C ;

DEPAEPE, A ;

DEVEREUX, R ;

RAMIREZ, F ;

PYERITZ, R .

NATURE GENETICS, 1995, 9 (03) :228-229

[8] Association of polymorphisms of the transforming growth factor-β1 gene with the rate of progression of HCV-induced liver fibrosis [J].

Gewaltig, J ;

Mangasser-Stephan, K ;

Gartung, C ;

Biesterfeld, S ;

Gressner, AM .

CLINICA CHIMICA ACTA, 2002, 316 (1-2) :83-94

[9]

GILCHRIST DM, 1994, AM J HUM GENET, V54, P553

[10] Mapping a locus for familial thoracic aortic aneurysms and dissections (TAAD2) to 3p24-25 [J].

Hasham, SN ;

Willing, MC ;

Guo, DC ;

Muilenburg, A ;

He, RM ;

Tran, VT ;

Scherer, SE ;

Shete, SS ;

Milewicz, DM .

CIRCULATION, 2003, 107 (25) :3184-3190

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