TGFβ signaling in health and disease

被引：115

作者：

Akhurst, RJ ^{[1
]}

机构：

[1] Univ Calif San Francisco, Mt Zion Canc Res Inst, San Francisco, CA 94143 USA

来源：

NATURE GENETICS | 2004年 / 36卷 / 08期

关键词：

D O I：

10.1038/ng0804-790

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Inactivating mutations in TGFBR2, encoding the transforming growth factor-beta (TGFbeta) type 2 receptor, may account for up to 10% of cases of Marfan syndrome. This finding has implications for a wider spectrum of disorders, including cancer, fibrosis and inflammatory and cardiovascular diseases, which are influenced by TGFbeta.

引用

页码：790 / 792

页数：4

共 15 条

[11] TGF-β1 gene polymorphisms in patients with end-stage heart failure [J].

Holweg, CTJ ;

Baan, CC ;

Niesters, HGM ;

Vantrimpont, PJMJ ;

Mulder, PGH ;

Maat, APWM ;

Weimar, W ;

Balk, AHMM .

JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2001, 20 (09) :979-984

[12] Fibrillin controls TGF-β activation [J].

Kaartinen, V ;

Warburton, D .

NATURE GENETICS, 2003, 33 (03) :331-332

[13] Heterozygous TGFBR2 mutations in Marfan syndrome [J].

Mizuguchi, T ;

Collod-Beroud, G ;

Akiyama, T ;

Abifadel, M ;

Harada, N ;

Morisaki, T ;

Allard, D ;

Varret, M ;

Claustres, M ;

Morisaki, H ;

Ihara, M ;

Kinoshita, A ;

Yoshiura, K ;

Junien, C ;

Kajii, T ;

Jondeau, G ;

Ohta, T ;

Kishino, T ;

Furukawa, Y ;

Nakamura, Y ;

Niikawa, N ;

Boileau, C ;

Matsumoto, N .

NATURE GENETICS, 2004, 36 (08) :855-860

[14] Transforming growth factor β1 gene polymorphism in rheumatoid arthritis [J].

Sugiura, Y ;

Niimi, T ;

Sato, S ;

Yoshinouchi, T ;

Banno, S ;

Naniwa, T ;

Maeda, H ;

Shimizu, S ;

Ueda, R .

ANNALS OF THE RHEUMATIC DISEASES, 2002, 61 (09) :826-828

[15] Genetic modifiers interact with maternal determinants in vascular development of Tgfb1-/- mice [J].

Tang, Y ;

McKinnon, ML ;

Leong, LM ;

Rusholme, SAB ;

Wang, SS ;

Akhurst, RJ .

HUMAN MOLECULAR GENETICS, 2003, 12 (13) :1579-1589

← 1 2 →