Prime movers of synaptic vesicle exocytosis

被引：54

作者：

Martin, TFJ ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

NEURON | 2002年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0896-6273(02)00651-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chemical synapses contain specialized pre- and postsynaptic structures that underlie rapid synaptic transmission and its modulation. Studies of postsynaptic organization have revealed a network of interacting proteins that enable rapid synaptic responses and their modulation. Recent genetic and electrophysiological studies on two active zone proteins-RIM and Munc13-reveal important roles in priming vesicles for Ca2+-triggered fusion and in mediating the regulation of this process. This work sheds new light on how presynaptic structure provides speed and plasticity to synaptic transmission.

引用

页码：9 / 12

页数：4

共 21 条

[1] Drosophila Unc-13 is essential for synaptic transmission
Aravamudan, B
Fergestad, T
Davis, WS
Rodesch, CK
Broadie, K
[J]. NATURE NEUROSCIENCE, 1999, 2 (11) : 965 - 971
[2] Munc13-1 is essential for fusion competence of glutamatergic synoptic vesicles
Augustin, I
Rosenmund, C
Südhof, TC
Brose, N
[J]. NATURE, 1999, 400 (6743) : 457 - 461
[3] Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming
Betz, A
Thakur, P
Junge, HJ
Ashery, U
Rhee, JS
Scheuss, V
Rosenmund, C
Rettig, J
Brose, N
[J]. NEURON, 2001, 30 (01) : 183 - 196
[4] Regulation of transmitter release by Unc-13 and its homologues
Brose, N
Rosenmund, C
Rettig, J
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) : 303 - 311
[5] RIM1α is required for presynaptic long-term potentiation
Castillo, PE
Schoch, S
Schmitz, F
Südhof, TC
Malenka, RC
[J]. NATURE, 2002, 415 (6869) : 327 - 330
[6] Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin
Coppola, T
Magnin-Lüthi, S
Perret-Menoud, V
Gattesco, S
Schiavo, G
Regazzi, R
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (35) : 32756 - 32762
[7] Molecular determinants of presynaptic active zones
Garner, CC
Kindler, S
Gundelfinger, ED
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) : 321 - 327
[8] The architecture of active zone material at the frog's neuromuscular junction
Harlow, ML
Ress, D
Stoschek, A
Marshall, RM
McMahan, UJ
[J]. NATURE, 2001, 409 (6819) : 479 - 484
[9] THE CYTOSKELETAL ARCHITECTURE OF THE PRESYNAPTIC TERMINAL AND MOLECULAR-STRUCTURE OF SYNAPSIN .1.
HIROKAWA, N
SOBUE, K
KANADA, K
HARADA, A
YORIFUJI, H
[J]. JOURNAL OF CELL BIOLOGY, 1989, 108 (01) : 111 - 126
[10] Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
Husi, H
Ward, MA
Choudhary, JS
Blackstock, WP
Grant, SGN
[J]. NATURE NEUROSCIENCE, 2000, 3 (07) : 661 - 669

← 1 2 3 →