Molecular determinants of presynaptic active zones

被引:156
作者
Garner, CC [1 ]
Kindler, S
Gundelfinger, ED
机构
[1] Univ Alabama Birmingham, Dept Neurobiol, Birmingham, AL 35294 USA
[2] Univ Hamburg, Inst Cellular Biochem & Clin Neurobiol, D-20246 Hamburg, Germany
[3] Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany
关键词
D O I
10.1016/S0959-4388(00)00093-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The presynaptic cytoskeletal matrix (cytomatrix) assembled at active zones has been implicated in defining neurotransmitter release sites. Munc13, Rim, Bassoon and Piccolo/Aczonin are recently identified presynaptic cytomatrix proteins. These multidomain proteins are thought to organize the exocytotic and endocytotic machinery precisely at active zones.
引用
收藏
页码:321 / 327
页数:7
相关论文
共 51 条
[1]   Drosophila Unc-13 is essential for synaptic transmission [J].
Aravamudan, B ;
Fergestad, T ;
Davis, WS ;
Rodesch, CK ;
Broadie, K .
NATURE NEUROSCIENCE, 1999, 2 (11) :965-971
[2]   Munc13-1 is essential for fusion competence of glutamatergic synoptic vesicles [J].
Augustin, I ;
Rosenmund, C ;
Südhof, TC ;
Brose, N .
NATURE, 1999, 400 (6743) :457-461
[3]   Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release [J].
Betz, A ;
Ashery, U ;
Rickmann, M ;
Augustin, I ;
Neher, E ;
Südhof, TC ;
Rettig, J ;
Brose, N .
NEURON, 1998, 21 (01) :123-136
[4]   Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina [J].
Brandstätter, JH ;
Fletcher, EL ;
Garner, CC ;
Gundelfinger, ED ;
Wässle, H .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (10) :3683-3693
[5]   Sustained neurotransmitter release:: New molecular clues [J].
Brodin, L ;
Löw, P ;
Gad, H ;
Gustafsson, J ;
Pieribone, VA ;
Shupliakov, O .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (12) :2503-2511
[6]   SYNAPTIC STRUCTURE AND FUNCTION - DYNAMIC ORGANIZATION YIELDS ARCHITECTURAL PRECISION [J].
BURNS, ME ;
AUGUSTINE, GJ .
CELL, 1995, 83 (02) :187-194
[7]   A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain [J].
Butz, S ;
Okamoto, M ;
Südhof, TC .
CELL, 1998, 94 (06) :773-782
[8]  
CasesLanghoff C, 1996, EUR J CELL BIOL, V69, P214
[9]   PDZ proteins organize synaptic signaling pathways [J].
Craven, SE ;
Bredt, DS .
CELL, 1998, 93 (04) :495-498
[10]   A role of amphiphysin in synaptic vesicle endocytosis suggested by its binding to dynamin in nerve terminals [J].
David, C ;
McPherson, PS ;
Mundigl, O ;
DeCamilli, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :331-335