Flavanols and procyanidins of cocoa and chocolate inhibit growth and polyamine biosynthesis of human colonic cancer cells

被引：94

作者：

Carnésecchi, S

Schneider, Y

Lazarus, SA

Coehlo, D

Gossé, F

Raul, F

机构：

[1] IRCAD, Lab Nutr Chemoprevent Digest Oncol, F-67091 Strasbourg, France

[2] Mars Inc Res & Dev, Hackettstown, NJ 07840 USA

[3] IRCAD, Mol Oncol Lab, F-67091 Strasbourg, France

来源：

CANCER LETTERS | 2002年 / 175卷 / 02期

关键词：

caco-2; cell; polyphenols; cell cycle; ornithine decarboxylase; putrescine;

D O I：

10.1016/S0304-3835(01)00731-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of cocoa powder and extracts with different amounts of flavanols and related procyanidin oligomers were investigated on the growth of Caco-2 cells. Treatment of the cells with 50 mug/ml of procyanidin-enriched (PE) extracts caused a 70% growth inhibition with a blockade of the cell cycle at the G2/M phase. PE extracts caused a significant decrease of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities, two key enzymes of polyamine biosynthesis. This led to a decrease in the intracellular pool of the polyamines. These observations indicate that polyamine metabolism might be an important target in the anti-proliferative effects of cocoa polyphenols. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：147 / 155

页数：9

共 34 条

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