A stereoselective synthetic approach to (2S,3R)-N-(1′ 1′-dimethyl-2′,3′-epoxypropyl)-3-hydroxytryptophan, a component of cyclomarin A

被引：20

作者：

Hansen, DB ^{[1
]}

Lewis, AS ^{[1
]}

Gavalas, SJ ^{[1
]}

Joullié, MM ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

TETRAHEDRON-ASYMMETRY | 2006年 / 17卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.tetasy.2005.10.040

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A stereoselective synthetic approach to (2S,3R)-N-(1',1'-dimethyl-2',3'-epoxypropyl)-3-hydroxytryptophan an amino acid contained in cyclomarin A was accomplished. The synthesis is based on a diastereoselective addition of an indole Grignard into a chiral serine aldehyde equivalent. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：15 / 21

页数：7

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