Precision and diversity in an odor map on the olfactory bulb

被引：237

作者：

Soucy, Edward R. ^{[1
,2
]}

Albeanu, Dinu F. ^{[1
,2
]}

Fantana, Antoniu L. ^{[1
,2
]}

Murthy, Venkatesh N. ^{[1
,2
]}

Meister, Markus ^{[1
,2
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

[2] Harvard Univ, Ctr Brain Sci, Cambridge, MA 02138 USA

来源：

NATURE NEUROSCIENCE | 2009年 / 12卷 / 02期

关键词：

INTRINSIC OPTICAL SIGNALS; RECEPTOR NEURON INPUT; STRUCTURAL FEATURES; MOLECULAR-FEATURES; MITRAL CELLS; MOUSE; SYSTEM; REPRESENTATION; ORGANIZATION; COMBINATORIAL;

D O I：

10.1038/nn.2262

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We explored the map of odor space created by glomeruli on the olfactory bulb of both rat and mouse. Identified glomeruli could be matched across animals by their response profile to hundreds of odors. Their layout in different individuals varied by only similar to 1 glomerular spacing, corresponding to a precision of 1 part in 1,000. Across species, mouse and rat share many glomeruli with apparently identical odor tuning, arranged in a similar layout. In mapping the position of a glomerulus to its odor tuning, we found only a coarse relationship with a precision of similar to 5 spacings. No chemotopic order was apparent on a finer scale and nearby glomeruli were almost as diverse in their odor sensitivity as distant ones. This local diversity of sensory tuning stands in marked distinction from other brain maps. Given the reliable placement of the glomeruli, it represents a feature, not a flaw, of the olfactory bulb.

引用

页码：210 / 220

页数：11

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