Severe Chronic Allergic (and Related) Diseases: A Uniform Approach - A MeDALL - GA2LEN - ARIA Position Paper

被引：80

作者：

Bousquet, J. ^{[1
,2
,6
]}

Anto, J. M. ^{[3
,4
,5
]}

Demoly, P. ^{[6
,7
]}

Schuenemann, H. J. ^{[8
]}

Togias, A. ^{[9
]}

Akdis, M. ^{[10
]}

Auffray, C. ^{[11
]}

Bachert, C. ^{[12
]}

Bieber, T. ^{[13
]}

Bousquet, P. J. ^{[1
,6
]}

Carlsen, K. H. ^{[14
]}

Casale, T. B. ^{[15
]}

Cruz, A. A. ^{[16
]}

Keil, T. ^{[17
]}

Carlsen, K. C. Lodrup ^{[14
]}

Maurer, M. ^{[18
]}

Ohta, K. ^{[19
]}

Papadopoulos, N. G. ^{[20
]}

Rodriguez, M. Roman ^{[21
]}

Samolinski, B. ^{[22
]}

Agache, I. ^{[23
]}

Andrianarisoa, A. ^{[24
]}

Ang, C. S. ^{[38
]}

Annesi-Maesano, I. ^{[25
,26
]}

Ballester, F. ^{[27
,28
]}

Baena-Cagnani, C. E. ^{[29
,30
]}

Basagana, X. ^{[3
,4
]}

Bateman, E. D. ^{[31
]}

Bel, E. H. ^{[32
]}

Bedbrook, A. ^{[6
]}

Beghe, B. ^{[33
,34
]}

Beji, M. ^{[35
]}

Ben Kheder, A. ^{[36
]}

Benet, M. ^{[3
,4
]}

Bennoor, K. S. ^{[37
]}

Bergmann, K. C. ^{[18
]}

Berrissoul, F. ^{[38
]}

Jensen, C. Bindslev ^{[39
]}

Bleecker, E. R. ^{[40
]}

Bonini, S. ^{[41
,42
]}

Boner, A. L. ^{[43
]}

Boulet, L. P. ^{[44
,45
]}

Brightling, C. E. ^{[46
]}

Brozek, J. L. ^{[8
]}

Bush, A. ^{[47
,48
]}

Busse, W. W. ^{[49
]}

Camargos, P. A. M. ^{[50
]}

Canonica, G. W. ^{[51
]}

Carr, W. ^{[52
]}

Cesario, A. ^{[53
,54
]}

机构：

[1] Hop Arnaud de Villeneuve, Dept Resp Dis, Univ Hosp, Montpellier, France

[2] INSERM, CESP Ctr Res Epidemiol & Populat Hlth, U1018, Resp & Environm Epidemiol Team, Villejuif, France

[3] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[4] IMIM Hosp Mar, Municipal Inst Med Res, Barcelona, Spain

[5] UPF, Barcelona, Spain

[6] WHO Collaborating Ctr Asthma & Rhinitis, Montpellier, France

[7] Hop Arnaud de Villeneuve, INSERM, U657, Univ Hosp Montpellier, Montpellier, France

[8] McMaster Univ, Dept Clin Epidemiol & Biostat & Med, Hamilton, ON, Canada

[9] NIAID, Bethesda, MD 20892 USA

[10] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[11] CNRS Inst Biol Sci, Villejuif, France

[12] Univ Hosp Ghent, URL Upper Airways Res Lab, Ghent, Belgium

[13] Univ Med Ctr, Dept Dermatol & Allergy, Bonn, Germany

[14] Univ Oslo, Oslo Univ Hosp, Dept Paediat, Oslo, Norway

[15] Creighton Univ, Dept Med, Div Allergy & Immunol, Omaha, NE 68178 USA

[16] Univ Fed Bahia, Sch Med, ProAR FMB, Salvador, BA, Brazil

[17] Charite, Inst Social Med Epidemiol & Hlth Econ, D-13353 Berlin, Germany

[18] Charite, Allergy Ctr Charite, Dept Dermatol, D-13353 Berlin, Germany

[19] Teikyo Univ, Sch Med, Dept Med, Div Resp Med & Allergol, Tokyo 173, Japan

[20] Univ Athens, Dept Allergy, Pediat Clin 2, Athens, Greece

[21] Son Pisa Primary Care Ctr, IB Salut Balear Hlth Serv, Palma de Mallorca, Spain

[22] Med Univ Warsaw, Dept Prevent Environm Hazards & Allergol, Warsaw, Poland

[23] Transylvania Univ, Fac Med, Brasov, Romania

[24] Minist Hlth, Publ Hosp Med Serv, Antananarivo, Madagascar

[25] INSERM, EPAR U707, Paris, France

[26] EPAR UMR S UPMC, Paris, France

[27] Univ Valencia, Valencia, Spain

[28] Ctr Publ Hlth Res CSISP, Valencia, Spain

[29] Catholic Univ, Fac Med, Cordoba, Argentina

[30] Univ Genoa, Sch Specializat, Genoa, Italy

[31] Univ Cape Town, Fac Hlth Sci, ZA-7925 Cape Town, South Africa

[32] Univ Amsterdam, Acad Med Ctr, Dept Pulmonol, NL-1012 WX Amsterdam, Netherlands

[33] Univ Southampton, Div Human Genet Infect, Sch Med, Southampton, Hants, England

[34] Univ Southampton, Div Human Genet Infect Inflammat & Repair, Sch Med, Southampton, Hants, England

[35] Ctr Hositalo Univ Rabta, Serv Pneumol Allergol, Tunis, Tunisia

[36] Hop A Mami, Ariana, Tunisia

[37] Natl Inst Dis Chest & Hosp, Dhaka, Bangladesh

[38] Natl Inst Dis Chest & Hosp, Air Khmer, Cambodia

[39] Odense Univ Hosp, DK-5000 Odense, Denmark

[40] Wake Forest Univ Hlth Sci, Winston Salem, NC USA

[41] Inst Neurobiol & Mol Med CNR, Rome, Italy

[42] Univ Naples 2, Dept Med, Naples, Italy

[43] Univ Verona, Dept Paediat, I-37100 Verona, Italy

[44] Hop Laval, Inst Cardiol & Pneumol, Quebec City, PQ, Canada

[45] Univ Laval, Quebec City, PQ, Canada

[46] Inst Lung Hlth, Leicester, Leics, England

[47] Royal Brompton Hosp, Dept Paediat Resp Med, London SW3 6LY, England

[48] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England

[49] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med, Madison, WI USA

[50] Univ Fed Minas Gerais, Sch Med, Dept Pediat, Belo Horizonte, MG, Brazil

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2012年 / 158卷 / 03期

关键词：

Immunoglobulin E; Asthma; Rhinitis; Rhinosinusitis; Urticaria; Atopic dermatitis; IMPORTANT RESEARCH QUESTIONS; WORLD-HEALTH-ORGANIZATION; QUALITY-OF-LIFE; ATOPIC-DERMATITIS; SEVERE ASTHMA; CHRONIC RHINOSINUSITIS; NASAL POLYPOSIS; NONALLERGIC RHINITIS; CLUSTER-ANALYSIS; ECZEMA AREA;

D O I：

10.1159/000332924

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies. Copyright (C) 2012 S. Karger AG, Basel

引用

页码：216 / 231

页数：16

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