Palladium(II) complexes of 2-acetylpyridine N(4)-propyl, N(4)-dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity. Synthesis, spectral properties, antifungal and in vitro antitumor activity

被引：81

作者：

KovalaDemertzi, D

Domopoulou, A

Demertzis, MA

Papageorgiou, A

West, DX

机构：

[1] THEAGENION KRANKENHAUSES,DEPT EXPT CHEMOTHERAPY,THESSALONIKI 54007,GREECE

[2] ILLINOIS STATE UNIV,DEPT CHEM,NORMAL,IL 61761

来源：

POLYHEDRON | 1997年 / 16卷 / 20期

关键词：

new palladium complexes; 2-acetylpyridine thiosemicarbazones; antitumor activity; METAL ION COMPLEXES; COPPER(II) COMPLEXES; REDOX BEHAVIOR; THIOSEMICARBAZONES; N-4-DIPROPYLTHIOSEMICARBAZONES; N-4-DIETHYLTHIOSEMICARBAZONES; ELECTROCHEMISTRY;

D O I：

10.1016/S0277-5387(97)00107-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Some new palladium(II) complexes of 2-acetylpyridine N(4)-propyl-and N(4)dipropyl- and 3-hexamethyleneiminylthiosemicarbazones with potentially interesting biological activity were described. The thiosemicarbazones and their palladium(II) complexes have been characterized by spectroscopic, and electrochemical techniques. The protonation constants of HAc4P K-a1 and K-a2, were determined by spectrophotometry and the pK(1a) and pK(a2) values are equal to 12.23 +/- 0.02 and 4.11 +/- 0.02. The antifungal properties and the effect selected compounds on DNA synthesis of P388 and L1210 cell cultures is reported. (C) 1997 Elsevier Science Ltd.

引用

页码：3625 / 3633

页数：9

共 21 条

[1] Synthesis, spectral and electrochemical properties of divalent metal complexes containing thiohydrazone and thiosemicarbazone ligands [J].